Do various CLINICIANS need to monitor Sirtuin 1 gene expression and plasma Sirtuin 1 levels with relevance to various drug therapies in patients?

Specific genes that are involved in anti-aging and epigenetics are sensitive to nutritional regulation, oxidative stress and the development of insulin resistance that can result from changes in cellular chromatin, DNA methylation and histone modifications with relevance to the global chronic disease epidemic. The defective gene in the global chronic disease epidemic has now been linked to the anti-aging gene Sirtuin 1. Nutritional regulation of Sirtuin 1 is critical to nuclear receptors/transcription factors that are involved with glucose homeostasis, immune system, body temperature regulation, stem cell therapy and mitochondrial biogenesis.  Sirtuin 1 is now an important gene for consideration in drug and pharmaceutical research.  

RELEVANT REFERENCES:

A.        Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. 2017;Vol. 3 No. 3:24. 

B.        Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26.

C.        Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals. International Journal of Aging Research. 2018,1(6): 1-4.

D.        The Future of Biomarkers Tests and Genomic Medicine in Global Organ Disease. Microbiology and Infectious Diseases. 2017; 1(1): 1-6. 7. 

E.         Early diagnosis of neuron mitochondrial dysfunction may reverse global metabolic and neurodegenerative disease. Global Journal of Medical Research.. 2016;2: 1-8. 10. 

F.         The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease. Proteomes, 2016. 4(2) 1-19.

G.        Early Diagnosis and Nutritional Treatment stabilizes Neuropsychiatric Disorders. Global Journal of Medical Research. 2018;1(1):1-7.

H.        Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions. EC Pharmacology and Toxicology 6.4 (2018): 209-215. 

I.          BODY TEMPERATURE REGULATION DETERMINES IMMUNE REACTIONS AND SPECIES LONGEVITY. Heat Shock Proteins in Neuroscience, 2019, Vol. 20, (Eds) Alexzander A. A. Asea and Punit Kaur. 2019.

J.          Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals. International Journal of Aging Research. 2018,1(6): 1-4.

K.        Evaluation of diagnostic tests in human health and disease. J Clin Path Lab Med. 2018;2(1):13-15.