Pings
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1 Answer 0 Votes
What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?
Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?
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0 Answers 0 Votes
What can be expected from the development of preventive vaccines for non virally-induced cancers?
The introduction of prophylactic vaccines for virally-induced cancers (primarily HBV and HPV) has achieved a tremendous impact on disease related deaths. This has, in time, raised interest in developing vaccines to intercept pre-cancerous cells based on their expression of aberrant self-antigens (e.g. hypoglycosilated MUC1 in colon, lung and breast carcinomas). As of 2024, a number of phase I clinical studies have been ongoing in the USA, for both primary prevention and early cancer...
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0 Answers 0 Votes
What is the current research progress on the role of the JAK/STAT/mTOR pathway in liver inflammation during liver failure, and is it considered a core pathway in this process?
I am studying the regulatory network of liver inflammation in the pathogenesis of liver failure, especially acute‑on‑chronic liver failure (ACLF). My current focus is on the phosphorylation activation of the JAK/STAT pathway and its downstream mTOR signaling in mediating hepatocyte death, macrophage polarization, and the inflammatory storm. I would like to know the latest research progress on this pathway—for example, whether it involves intercellular crosstalk—and whether the JAK/STAT/mTOR...
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Answer Accepted 2 Answers 2 Votes
What constitutes evidence when the links between exposure and outcome are indirect, delayed, or influenced by multiple interacting factors? And how can we strengthen our ability to interpret patterns
In modern research and public health, phenomena occur in complex systems where biological, environmental, and social factors interact over time. Causality is rarely linear or clear. Understanding these requires evaluating study design, uncertainty, and context, and critically analyzing how evidence is generated, interpreted, and used in decision-making.
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3 Answers 0 Votes
Does peer review continue to be the best standard for ascertaining whether a manuscript is suitable for publication?
I am sure that all of us have encountered peer reviewers who are neither 'peers' in the true spirit of the word, or even good reviewers based on the quality of their reviews. However, most (?almost all) journal editors are somewhat reluctant to look past a reviewers recommendation and exercise their editorial prerogative. As a result, good research suffers! So what can be done? I don't have an answer but am looking for insightful comments/options. Thanks.
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3 Answers 0 Votes
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
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2 Answers 0 Votes
Why is the ammonia/ammonium concentration highly increased during storage of human urine?
Hydrolysis of urine Why is the ammonia/ammonium concentration highly increased during storage of human urine?
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Answer Accepted 1 Answer 0 Votes
What are the current hot topics in the study of critical points during the process of cell mutation and development into tumors? How to conduct in-depth research on the future use of AI?
Tumorigenesis is not a linear accumulation of mutations but rather a dynamic process punctuated by critical transition points—windows during which normal cells cross irreversible thresholds toward dysplasia, carcinoma in situ, and ultimately invasive malignancy. Understanding the molecular and ecological drivers of these “tipping points” is fundamental to early interception and prevention. I would like to ask the cancer biology and computational oncology community: Which specific transition...
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Answer Accepted 7 Answers 4 Votes
No threshold approach in the risk assessment of genotoxic carcinogen. Is it still well supported by current knowledge of carcinogenesis?
No threshold approach is routinely applied in the risk assessment of genotoxic carcinogens. How this approach is supported by data? Isn´ t it somewhat obsolete?
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5 Answers 0 Votes
How do microplastic particle sizes influence bioaccumulation and toxicity in freshwater ecosystems?
Microplasticsand plastic particles smaller than 5 mm are increasingly found in rivers, lakes, and reservoirs worldwide. Their small size allows them to be ingested by a wide range of aquatic organisms, potentially moving up the food chain. Research suggests that particle size may influence how these plastics are taken up, accumulate in tissues, and cause physiological effects, but the mechanisms are still not well understood. Understanding these size-dependent effects is essential for...
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