Pings
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3 Answers 0 Votes
How can advances in electrochemical CO₂ conversion improve scalability of carbon-to-fuel technologies while minimizing energy demand and byproduct formation?
As a specialist in CO₂ reduction, my work focuses on advancing pathways that move beyond capture and storage toward scalable, value-added solutions. Current approaches including mineralization, electrochemical conversion, and bio-catalytic processes show potential but face challenges of efficiency, energy demand, and long-term stability. A critical next step is identifying how chemical, mineral, or catalytic enhancements can accelerate these processes while maintaining sustainability and...
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Answer Accepted 1 Answer 0 Votes
How does STAT3 contribute to intestinal mucosal barrier function, particularly during mucosal repair after injury?
Elucidating the role of STAT3 in intestinal epithelial regeneration and barrier integrity is critical for understanding IBD pathogenesis and tissue recovery. Key aspects include: 1.Epithelial-specific vs. immune-cell STAT3 signaling in wound healingDownstream targets (e.g., mucins, 2.tight junction proteins) mediating barrier protectionContext-dependent effects: protective versus pro-inflammatory roles 3.Insights could inform therapeutic strategies for mucosal healing. Relevant diagrams or...
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10 Answers 1 Vote
Can we consider that epidrugs can constitute a good therapeutic strategy against cancer diseases?
Recently, it has been demonstrated that epigenetic perturbations are mainly involved in cancer development. Can we consider that epidrugs can constitute a good therapeutic strategy against cancer diseases ?
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Answer Accepted 1 Answer 1 Vote
What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?
Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?
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3 Answers 0 Votes
Does peer review continue to be the best standard for ascertaining whether a manuscript is suitable for publication?
I am sure that all of us have encountered peer reviewers who are neither 'peers' in the true spirit of the word, or even good reviewers based on the quality of their reviews. However, most (?almost all) journal editors are somewhat reluctant to look past a reviewers recommendation and exercise their editorial prerogative. As a result, good research suffers! So what can be done? I don't have an answer but am looking for insightful comments/options. Thanks.
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Answer Accepted 1 Answer 0 Votes
What are the current hot topics in the study of critical points during the process of cell mutation and development into tumors? How to conduct in-depth research on the future use of AI?
Tumorigenesis is not a linear accumulation of mutations but rather a dynamic process punctuated by critical transition points—windows during which normal cells cross irreversible thresholds toward dysplasia, carcinoma in situ, and ultimately invasive malignancy. Understanding the molecular and ecological drivers of these “tipping points” is fundamental to early interception and prevention. I would like to ask the cancer biology and computational oncology community: Which specific transition...
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6 Answers 4 Votes
How might AI-assisted peer review tools reshape scientific publishing, and what safeguards should be implemented to maintain review quality while addressing the increasing volume of submissions?
The peer-reviewing process is being faced with ever-growing challenges as submission rates are still rising exponentially in all areas. Journal editors are faced with the challenge of getting capable reviewers who are ready to volunteer their time, with a result being delays in reviewing, reviewer exhaustion, and worse, compromised quality. Meanwhile, AI technologies are accelerating their ability to review scientific manuscripts for methodology, statistical fitting, plagiarism screenings,...
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15 Answers 1 Vote
How should irrelevant comment(s) from a peer reviewer be handled?
Some times an irrelevant comments is made on a peer review report based on which a paper is rejected and that makes the author very discouraging. Like "Proper discussion is not made why apple is red" while the paper is on lily flower. The answer could be any of the same a) The editorial board should take care of such comments and provide the full support to evaluate the paper a s per merit rather than rejection. b) The paper be rejected and resubmitted to the same or other Journal citing the...
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8 Answers 4 Votes
How do you justify (or would you justify) a new research study to ensure it doesn’t unnecessarily duplicate previous work or repeat past methodological mistakes?
I’m currently working on a PhD thesis focused on Evidence-Based Research (EBR), particularly on how researchers use (or fail to use) prior evidence (similar studies), to justify and design new research. I’d love to hear real-world experiences, whether from preparing research proposals or evaluating them. Do you use any structured or unstructured method to be aware of all relevant prior research? How do you support your judgments (e.g., demonstrating that no prior studies exist, or that...
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14 Answers 0 Votes
Should a big research (e.g., PhD) be published as one comprehensive high-impact paper or several smaller, faster publications?
Should a big study perhaps a PhD student’s research be published as one comprehensive, high-impact paper or split into several smaller, focused publications? A single major paper can offer a cohesive, in-depth contribution with broader impact, but may delay dissemination. Multiple smaller papers can communicate findings more quickly and stimulate ongoing research, yet may lack the unified context of a larger work. What choice is the best - having a comprehensive paper in high impact journals...
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