Pings
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3 Answers 0 Votes
How can advances in electrochemical CO₂ conversion improve scalability of carbon-to-fuel technologies while minimizing energy demand and byproduct formation?
As a specialist in CO₂ reduction, my work focuses on advancing pathways that move beyond capture and storage toward scalable, value-added solutions. Current approaches including mineralization, electrochemical conversion, and bio-catalytic processes show potential but face challenges of efficiency, energy demand, and long-term stability. A critical next step is identifying how chemical, mineral, or catalytic enhancements can accelerate these processes while maintaining sustainability and...
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6 Answers 0 Votes
How to examine for power of grip in a patient with weakness?
When we do clinical examination for weakness, power is ascertained by MRC grading. However, for grip, MRC grading cannot be used. Is there any method to examine hand grip power other than using dynamometer
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Answer Accepted 1 Answer 0 Votes
What is the current research progress on the role of the JAK/STAT/mTOR pathway in liver inflammation during liver failure, and is it considered a core pathway in this process?
I am studying the regulatory network of liver inflammation in the pathogenesis of liver failure, especially acute‑on‑chronic liver failure (ACLF). My current focus is on the phosphorylation activation of the JAK/STAT pathway and its downstream mTOR signaling in mediating hepatocyte death, macrophage polarization, and the inflammatory storm. I would like to know the latest research progress on this pathway—for example, whether it involves intercellular crosstalk—and whether the JAK/STAT/mTOR...
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Answer Accepted 1 Answer 0 Votes
How does STAT3 contribute to intestinal mucosal barrier function, particularly during mucosal repair after injury?
Elucidating the role of STAT3 in intestinal epithelial regeneration and barrier integrity is critical for understanding IBD pathogenesis and tissue recovery. Key aspects include: 1.Epithelial-specific vs. immune-cell STAT3 signaling in wound healingDownstream targets (e.g., mucins, 2.tight junction proteins) mediating barrier protectionContext-dependent effects: protective versus pro-inflammatory roles 3.Insights could inform therapeutic strategies for mucosal healing. Relevant diagrams or...
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Answer Accepted 2 Answers 0 Votes
Artificial intelligence has brought great hope to advancing our understanding of severe inflammation by simulating complex signal networks and molecular mechanisms that determine disease trajectories.
Artificial intelligence has brought great hope to advancing our understanding of severe inflammation by simulating complex signal networks and molecular mechanisms that determine disease trajectories. The core of this work is pathways such as NF - κ B, MAPK, and JAK-STAT, which regulate the expression of pro-inflammatory cytokines and mediators. These pathways are regulated by post-translational modifications, transcription factor dynamics, and crosstalk with damage associated molecular...
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25 Answers 54 Votes
For respiratory viruses, should folks wear masks in public a) always, b) if they are or may be infected, or c) if they are afraid of getting infected? Are masks a) protection, or b) social signals?
Since 2020, the public has thought of masks as having a protective purpose, and many rebel at the inconvenience, rationalizing that “they do a poor job of protecting.” Is the current epidemic a good opportunity for government and medicine to teach the folks about the more important virtues of using masks to convey information?
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Answer Accepted 1 Answer 1 Vote
What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?
Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?
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3 Answers 0 Votes
Does peer review continue to be the best standard for ascertaining whether a manuscript is suitable for publication?
I am sure that all of us have encountered peer reviewers who are neither 'peers' in the true spirit of the word, or even good reviewers based on the quality of their reviews. However, most (?almost all) journal editors are somewhat reluctant to look past a reviewers recommendation and exercise their editorial prerogative. As a result, good research suffers! So what can be done? I don't have an answer but am looking for insightful comments/options. Thanks.
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6 Answers 4 Votes
How might AI-assisted peer review tools reshape scientific publishing, and what safeguards should be implemented to maintain review quality while addressing the increasing volume of submissions?
The peer-reviewing process is being faced with ever-growing challenges as submission rates are still rising exponentially in all areas. Journal editors are faced with the challenge of getting capable reviewers who are ready to volunteer their time, with a result being delays in reviewing, reviewer exhaustion, and worse, compromised quality. Meanwhile, AI technologies are accelerating their ability to review scientific manuscripts for methodology, statistical fitting, plagiarism screenings,...
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15 Answers 1 Vote
How should irrelevant comment(s) from a peer reviewer be handled?
Some times an irrelevant comments is made on a peer review report based on which a paper is rejected and that makes the author very discouraging. Like "Proper discussion is not made why apple is red" while the paper is on lily flower. The answer could be any of the same a) The editorial board should take care of such comments and provide the full support to evaluate the paper a s per merit rather than rejection. b) The paper be rejected and resubmitted to the same or other Journal citing the...
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