Pings
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Answer Accepted 2 Answers 0 Votes
What can be expected from the development of preventive vaccines for non virally-induced cancers?
The introduction of prophylactic vaccines for virally-induced cancers (primarily HBV and HPV) has achieved a tremendous impact on disease related deaths. This has, in time, raised interest in developing vaccines to intercept pre-cancerous cells based on their expression of aberrant self-antigens (e.g. hypoglycosilated MUC1 in colon, lung and breast carcinomas). As of 2024, a number of phase I clinical studies have been ongoing in the USA, for both primary prevention and early cancer...
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Answer Accepted 1 Answer 1 Vote
What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?
Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?
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Answer Accepted 1 Answer 0 Votes
What are the current hot topics in the study of critical points during the process of cell mutation and development into tumors? How to conduct in-depth research on the future use of AI?
Tumorigenesis is not a linear accumulation of mutations but rather a dynamic process punctuated by critical transition points—windows during which normal cells cross irreversible thresholds toward dysplasia, carcinoma in situ, and ultimately invasive malignancy. Understanding the molecular and ecological drivers of these “tipping points” is fundamental to early interception and prevention. I would like to ask the cancer biology and computational oncology community: Which specific transition...
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Answer Accepted 2 Answers 1 Vote
As an editor for peer-reviewed journal, what would you consider appropriate in making a decision to accept a peer-reviewer's report?
When evaluating a peer-reviewed study on surface water resources used for a commercial water operation, it is expected that the reviewer will thoroughly assess the methodology, including water sampling procedures and data analysis. In addition, the reviewer should identify potential oversights and suggest necessary improvements or alternative methods. However, when an expert reviewer raises concerns, and the authors respond with contrary submissions supported by well-detailed references, how...
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Answer Accepted 1 Answer 0 Votes
What is the level of study with the highest level of scientific evidence in the health area?
1️⃣ Individual-level meta-analysis – Reanalyzes raw data from multiple studies for more accurate answers. 2️⃣ Network meta-analysis – Connects treatments that have never been directly compared, ranking their effectiveness. 3️⃣ Dose-response meta-analysis – Reveals the impact of different doses on clinical outcomes.
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Answer Accepted 10 Answers 3 Votes
Do co-authors in low and middle income countries (LMICs) really engage in a research paper they are listed?
Number of published research papers were among the criteria of promotions for academic staffs and researchers in many localities. This might have been caused biased and false publications in resource limited countries. Should researchers study researchers?
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Answer Accepted 1 Answer 0 Votes
Are there concrete examples that genomics research or genomic selection led to superior crop cultivars?
Numerous articles predict that genomics research and genomic selection would accelerate plant breeding. We have been conducting a study to see how much more effective is genomic selection relative to conventional visual selection in plant cultivar development for a number of years and are about to write a summary article. We are interested in knowing similar researches and their results and conclusions.
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Answer Accepted 7 Answers 2 Votes
Data fabrication, p-hacking and biased peer review are issues with published papers. In your opinion, how can we fix this problem as a scientific community?
Recently, these issues have been brought up in many fields, resulting in retraction of important papers and investigation on the data produced by prominent scientists. That undermines the trust I used to put in published data, granted that we are always skeptical in science, but we always move forward basing our new hypothesis on what has been published. I wonder how can we help to improve the trustworthiness of published data.
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Answer Accepted 2 Answers 0 Votes
How can I keep bronchial epithelial cell alive, while retaining the effect of PM exposure?
Objective of the study: Evaluate whether normal bronchial epithelial cells acquire invasiveness following exposure to particulate matter. Initial approach: Expose the BEAS2B cell line to PM10 at concentrations of 50ug and 75ug for 48 hours. Subsequently, perform a wound healing assay and an invasion assay using matrigel. Problem encountered: Post exposure, a significant number of cells died, resulting in inadequate cell viability. This has hindered our ability to observe if the non-malignant...
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Answer Accepted 5 Answers 5 Votes
Why do cancer treatment options (chemotherapies + radiations) have outcome failure rates of 90% (+/-5) for solid tumors?
Despite seven decades of basic science, epidemiological and animal studies or clinical trials on cancer research and therapy, why cancer treatment options (chemotherapies + radiations) have outcome failure rates of 90% (+/-5) for solid tumors, according to governmental and private organizations. Please select your answer among the followings: 1. Need more research funding for epidemiological studies and experimental models of tumors and clinical trials. 2. Cancer is too many (100, 200...
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