Pings
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Answer Accepted 1 Answer 1 Vote
What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?
Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?
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Answer Accepted 6 Answers 7 Votes
Do recurring evaluations by research funders genuinely enhance research quality and societal impact, or do they merely create unnecessary administrative burdens?
Many research funders require periodic evaluations of projects to ensure accountability, monitor progress, and assess impact. While such evaluations can drive improvements in research design, transparency, and relevance, they can also consume significant time and resources. This raises the question of whether the benefits—such as higher-quality outputs and stronger societal contributions—outweigh the potential drawbacks, including administrative overload and reduced time for actual research.
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Answer Accepted 1 Answer 0 Votes
When turning at intersections, how difficult do you find it to detect pedestrians on the crosswalk? And how helpful do you think visual or sound warnings (like lights or beeps) would be?
Turning at intersections presents a common challenge for drivers, especially when pedestrians are crossing from the left or right side. Detecting pedestrians in these situations can be difficult due to blind spots, A-pillar obstruction, distractions, and poor visibility (e.g., nighttime, fog, or busy environments). To enhance safety, researchers and manufacturers are exploring pedestrian warning systems that use visual (e.g., LED lights) and auditory (e.g., beep sounds) alerts to help drivers...
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Answer Accepted 2 Answers 0 Votes
In developing bioresorbable metallic implants for bone applications, what do you think are the biggest challenges?
Presently, a lot of research is going on based on magnesium, zinc, and iron for being used as temporary implants for orthopedic applications. Despite its advantages, widespread adoption in clinical settings still presents numerous challenges.
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Answer Accepted 7 Answers 7 Votes
How publication retractions should be handled?
With an alarming rise in number of retracted papers, what the scientific community thinks is the best way to handle them? 1. Should be ignored, giving benefit-of-doubt to the authors 2. Authors with multiple retracted papers should be demoted 3. Organizations with high retraction rates should be banned from entering various rankings, and debar them from government funding for 1-2 years 4. Court trials against the faulty researchers for criminal wastage of public money
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Answer Accepted 1 Answer 0 Votes
What do you think about post-publication review? Should it be adopted more widely?
Conventional peer-review takes quite long, and is one of the major reasons for the snail-pace of the publication process. On the other hand, it seems attractive to quickly make your article public as a preprint (e.g. on bioRxiv), so that it can get readership and may be citations even before formal publication. Some journals (F1000Research, eLife, etc.) have started the practice of post-publication review. Here 'publication' means not 'acceptance', but making the article public with a valid...
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Answer Accepted 18 Answers 22 Votes
Could salary be used as a surrogate for smoking when sample data are lacking?
In epidemiology cohort studies, information on smoking status is often times lacking for the study sample, which makes it challenging to characterize the effects of other risk factors on endpoints that are causally related to smoking (e.g., lung cancer mortality). Given the strong inverse reported for smoking and income, could salary be used as a surrogate for smoking when direct data are lacking? or would potential relationships between salary other risk factors (e.g., health care access)...
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Answer Accepted 1 Answer 0 Votes
For me-too medical devices, on what basis should manufacturers choose biological tests to conduct?
Manufacturers producing a me-too medical device intended for implantation in the human body, conducting a full biocompatibility study including implantation effect that takes more than one year does not seem logical. With the availability of a reference medical device of the same material & intended use, how can the manufacturer choose the required biological tests?
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Answer Accepted 1 Answer 1 Vote
How the drug dosing space and therapeutic level in term of MTD may best be correlated with pharmacokinetics and body metabolic rate in the subject to gain best possible impact and to minimize the toxicity.
when we recommend the dose of antibiotics like oxytetracycline in animals we usually take into consideration the recommended dose on the label but most of the time the therapeutic effect may not be obtained as suspected. As physician we recommend little bit high dose of the drug in some animals for best results which becomes beyond the regulation authorities to justify. Is it possible to recommend the dosing space or dose of the drug flexible including some criteria of considering BMR of the...
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Complete 32 Answers 180 Votes
What questions would you like the SciPinion Community to address next in a SciPoll? $100
SciPinion is seeking your input for our upcoming SciPolls. Please participate in this SciPinion Ping (a single science-based question posted for other experts to answer) by posting your top multiple-choice question, including answer options. If you participate you will earn Ping credits to ask your own questions and if we choose your question, there is a $100 reward. We will choose at least one of the most popular and thought provoking questions. Please post your topic in the form of a...
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