Pings
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6 Answers 5 Votes
How should exposure durations be scaled from studies in mice and rats to humans?
Time-Scaling for Developmental Toxicity Endpoints How should exposure durations be scaled from studies in mice and rats to humans? Is a 10-day rodent exposure equivalent to a 10-day human exposure during gestation?
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1 Answer 0 Votes
How is it possible to say how long the medical implants that are inside the human body will function?
The functional lifespan of implants placed inside the body How we can trust or know that an implant will work for a specific period?
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18 Answers 8 Votes
Is Oxidative Stress sufficient by itself as an indicator and compelling basis for a carcinogenic concern?
Oxidative Stress as a Precursor and Mechanism for Carcinogenicity IARC and others (Smith et al) have identified 10 key characteristics which may be used/considered in the evaluation of carcinogenicity, one of which is oxidative stress. How strong or compelling, if at all, would the data need to be for considering OS as a putative and defensible MOA for carcinogenicity, or would there need to be other tangential/correlative data (e.g., tumors) available. In other words, is OS sufficient by...
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10 Answers 0 Votes
The motivation behind conducting a risk assessment
Hello, I understand the purpose of a chemical risk assessment (e.g., setting safe exposure limits). However, I am wondering, in practical terms, what (aside from regulations) causes agencies to conduct these assessments. Consumer concerns? Potential litigation? Political pressure? In other words, what signals do the EPA and other regulatory agencies get that convinces them to conduct an assessment? Thank you.
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