Pings
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0 Answers 0 Votes
What technological revolutions are needed for the most likely curative breakthrough in cancer treatment?
What disruptive technological revolutions are most needed to achieve a truly curative breakthrough? For example, universal CAR-T, personalized neoantigen vaccines, in situ gene editing, and new mechanisms to overcome drug resistance and metastasis. Please express your own opinions
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7 Answers 5 Votes
How might AI-assisted peer review tools reshape scientific publishing, and what safeguards should be implemented to maintain review quality while addressing the increasing volume of submissions?
The peer-reviewing process is being faced with ever-growing challenges as submission rates are still rising exponentially in all areas. Journal editors are faced with the challenge of getting capable reviewers who are ready to volunteer their time, with a result being delays in reviewing, reviewer exhaustion, and worse, compromised quality. Meanwhile, AI technologies are accelerating their ability to review scientific manuscripts for methodology, statistical fitting, plagiarism screenings,...
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3 Answers 0 Votes
It seems Duffy negativity does not offer a 100% resistance to vivax malaria in Africans; any clues as to why this is so?????
Duffy polymorphism and malaria, any link?
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7 Answers 3 Votes
For a change in the peer-reveiwing as an urgent need?
With an increasing number of Journal and other publication, the review by peer started to be difficult and very often nonqualified reviewers are solicited. Very often now the Journal send us a list that ressemble the directory a. This is a problem since many of the persons listed here do not have even a record over 10 and there are supposed to review works they don't know, and they are not qualified. I would like to start a huge discussion that can be sent to the main Journal to change the...
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4 Answers 0 Votes
How can deep learning architectures be designed to improve generalization under limited or noisy training data while maintaining robustness and interpretability?
Deep learning models have achieved remarkable performance across domains such as computer vision, natural language processing, and scientific modeling. However, challenges remain in areas including generalization beyond training distributions, interpretability of learned representations, and robustness to noisy or limited datasets. I am particularly interested in understanding which architectural innovations, training strategies, or theoretical insights have shown the most promise in...
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6 Answers 0 Votes
How to examine for power of grip in a patient with weakness?
When we do clinical examination for weakness, power is ascertained by MRC grading. However, for grip, MRC grading cannot be used. Is there any method to examine hand grip power other than using dynamometer
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6 Answers 0 Votes
What deep learning strategies best balance accuracy and interpretability in medical image segmentation for disease progression analysis?
Medical imaging (CT/MRI) segmentation is vital for tracking disease, but black-box models reduce clinical trust. Methods like explainable AI (XAI), uncertainty quantification, and hybrid modeling may bridge this gap. What approaches are most promising?
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25 Answers 54 Votes
For respiratory viruses, should folks wear masks in public a) always, b) if they are or may be infected, or c) if they are afraid of getting infected? Are masks a) protection, or b) social signals?
Since 2020, the public has thought of masks as having a protective purpose, and many rebel at the inconvenience, rationalizing that “they do a poor job of protecting.” Is the current epidemic a good opportunity for government and medicine to teach the folks about the more important virtues of using masks to convey information?
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2 Answers 0 Votes
Why is the ammonia/ammonium concentration highly increased during storage of human urine?
Hydrolysis of urine Why is the ammonia/ammonium concentration highly increased during storage of human urine?
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14 Answers 2 Votes
Why is the death rate of male in heart disease always higher than that of women? How can a male achieve that power?
It is clear from the report of WHO that the death rate of Male in heart-disease is higher than that of women. This observation suggests that the woman may have some physical advantage. Besides, differential food, beverage-drinking, and smoking habit, etc. can also contribute to it. For example, the habit of consuming oily foods (saturated fat harms heart) is more in the case of some individuals (taste matter). Although many people are aware of the issue, they can't change the food-habits....
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