Pings
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1 Answer 0 Votes
What are the key immune mechanisms underlying transplant tolerance, and which novel strategies show promise for clinically safe rejection prevention?
Despite the continuous progress of immunosuppressants, long-term transplant rejection and drug toxicity remain major challenges. Transplant tolerance (a donor specific immune non responsive state that does not rely on sustained immune suppression) remains a difficult goal to achieve. The key mechanisms include central and peripheral immune regulation (such as regulatory T cells, immune exhaustion, clonal clearance, myeloid suppressor cells, etc.). The new strategies include co stimulatory...
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0 Answers 0 Votes
What technological revolutions are needed for the most likely curative breakthrough in cancer treatment?
What disruptive technological revolutions are most needed to achieve a truly curative breakthrough? For example, universal CAR-T, personalized neoantigen vaccines, in situ gene editing, and new mechanisms to overcome drug resistance and metastasis. Please express your own opinions
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7 Answers 5 Votes
How might AI-assisted peer review tools reshape scientific publishing, and what safeguards should be implemented to maintain review quality while addressing the increasing volume of submissions?
The peer-reviewing process is being faced with ever-growing challenges as submission rates are still rising exponentially in all areas. Journal editors are faced with the challenge of getting capable reviewers who are ready to volunteer their time, with a result being delays in reviewing, reviewer exhaustion, and worse, compromised quality. Meanwhile, AI technologies are accelerating their ability to review scientific manuscripts for methodology, statistical fitting, plagiarism screenings,...
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7 Answers 3 Votes
For a change in the peer-reveiwing as an urgent need?
With an increasing number of Journal and other publication, the review by peer started to be difficult and very often nonqualified reviewers are solicited. Very often now the Journal send us a list that ressemble the directory a. This is a problem since many of the persons listed here do not have even a record over 10 and there are supposed to review works they don't know, and they are not qualified. I would like to start a huge discussion that can be sent to the main Journal to change the...
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4 Answers 0 Votes
How can deep learning architectures be designed to improve generalization under limited or noisy training data while maintaining robustness and interpretability?
Deep learning models have achieved remarkable performance across domains such as computer vision, natural language processing, and scientific modeling. However, challenges remain in areas including generalization beyond training distributions, interpretability of learned representations, and robustness to noisy or limited datasets. I am particularly interested in understanding which architectural innovations, training strategies, or theoretical insights have shown the most promise in...
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6 Answers 0 Votes
What deep learning strategies best balance accuracy and interpretability in medical image segmentation for disease progression analysis?
Medical imaging (CT/MRI) segmentation is vital for tracking disease, but black-box models reduce clinical trust. Methods like explainable AI (XAI), uncertainty quantification, and hybrid modeling may bridge this gap. What approaches are most promising?
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2 Answers 0 Votes
What are the potentials and ethical challenges that CRISPR-Cas9 technology is opening up in modern medicine?
CRISPR-Cas9, a revolutionary gene-editing tool, allows scientists to precisely cut and paste DNA sequences. This capability opens vast possibilities for medicine, but also brings significant ethical dilemmas.
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11 Answers 5 Votes
How to quickly check the purity of primary cultures of neurons
Any quick method to test purity of primary cultures of neurons (after 17 days of culture, right before using them for signaling assays)?
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12 Answers 3 Votes
Any herbal medicines used for hepatitis, possible mechanism of action, and if possible attached pictures of plants with citations
Any herbal medicines used for hepatitis, possible mechanism of action, and if possible attached pictures of plants with citations
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7 Answers 0 Votes
How long does it take for a glycoprotein to be synthesised de novo, processed in the ER/Golgi apparatus and transported to the cell membrane?
The trafficking time probably depends on the specific protein, but a ballpark average time is what I'm after. Please include references or examples.
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