Pings
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0 Answers 0 Votes
What technological revolutions are needed for the most likely curative breakthrough in cancer treatment?
What disruptive technological revolutions are most needed to achieve a truly curative breakthrough? For example, universal CAR-T, personalized neoantigen vaccines, in situ gene editing, and new mechanisms to overcome drug resistance and metastasis. Please express your own opinions
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7 Answers 5 Votes
How might AI-assisted peer review tools reshape scientific publishing, and what safeguards should be implemented to maintain review quality while addressing the increasing volume of submissions?
The peer-reviewing process is being faced with ever-growing challenges as submission rates are still rising exponentially in all areas. Journal editors are faced with the challenge of getting capable reviewers who are ready to volunteer their time, with a result being delays in reviewing, reviewer exhaustion, and worse, compromised quality. Meanwhile, AI technologies are accelerating their ability to review scientific manuscripts for methodology, statistical fitting, plagiarism screenings,...
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3 Answers 0 Votes
It seems Duffy negativity does not offer a 100% resistance to vivax malaria in Africans; any clues as to why this is so?????
Duffy polymorphism and malaria, any link?
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4 Answers 0 Votes
How can deep learning architectures be designed to improve generalization under limited or noisy training data while maintaining robustness and interpretability?
Deep learning models have achieved remarkable performance across domains such as computer vision, natural language processing, and scientific modeling. However, challenges remain in areas including generalization beyond training distributions, interpretability of learned representations, and robustness to noisy or limited datasets. I am particularly interested in understanding which architectural innovations, training strategies, or theoretical insights have shown the most promise in...
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6 Answers 0 Votes
How to examine for power of grip in a patient with weakness?
When we do clinical examination for weakness, power is ascertained by MRC grading. However, for grip, MRC grading cannot be used. Is there any method to examine hand grip power other than using dynamometer
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6 Answers 0 Votes
What deep learning strategies best balance accuracy and interpretability in medical image segmentation for disease progression analysis?
Medical imaging (CT/MRI) segmentation is vital for tracking disease, but black-box models reduce clinical trust. Methods like explainable AI (XAI), uncertainty quantification, and hybrid modeling may bridge this gap. What approaches are most promising?
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25 Answers 54 Votes
For respiratory viruses, should folks wear masks in public a) always, b) if they are or may be infected, or c) if they are afraid of getting infected? Are masks a) protection, or b) social signals?
Since 2020, the public has thought of masks as having a protective purpose, and many rebel at the inconvenience, rationalizing that “they do a poor job of protecting.” Is the current epidemic a good opportunity for government and medicine to teach the folks about the more important virtues of using masks to convey information?
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0 Answers 0 Votes
In what way is fluence-dependent photobiomodulation at 660 nm modulating mitochondrial-driven motility and acrosomal membrane stability in human spermatozoa, and can a simulation-based model incorpora
This question integrates: Biophysical mechanisms (mitochondrial activity, acrosomal membrane) Photobiomodulation parameters (fluence, wavelength) Computational modeling (simulation-based, biological noise) Clinical translation (fertility optimization
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2 Answers 0 Votes
What are the potentials and ethical challenges that CRISPR-Cas9 technology is opening up in modern medicine?
CRISPR-Cas9, a revolutionary gene-editing tool, allows scientists to precisely cut and paste DNA sequences. This capability opens vast possibilities for medicine, but also brings significant ethical dilemmas.
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3 Answers 2 Votes
What reduces the human body's response to medications even though they are appropriate for his condition? What is the solution to this crisis?
What reduces the human body's response to medications even though they are appropriate for his condition? What is the solution to this crisis?
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