Pings
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1 Answer 0 Votes
What are the current hot topics in the study of critical points during the process of cell mutation and development into tumors? How to conduct in-depth research on the future use of AI?
Tumorigenesis is not a linear accumulation of mutations but rather a dynamic process punctuated by critical transition points—windows during which normal cells cross irreversible thresholds toward dysplasia, carcinoma in situ, and ultimately invasive malignancy. Understanding the molecular and ecological drivers of these “tipping points” is fundamental to early interception and prevention. I would like to ask the cancer biology and computational oncology community: Which specific transition...
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0 Answers 0 Votes
What are the most popular directions in tumor immune research that can be linked to traditional Chinese medicine at present?
Traditional Chinese medicine has long been practiced in cancer care, yet its mechanistic interface with modern tumor immunology remains underexplored. Given the recent advances in immuno-oncology—particularly in areas such as gut microbiota modulation, tumor microenvironment reprogramming, metabolic reprogramming of immune cells, and reversal of T cell exhaustion—I am interested in identifying which of these frontiers offer the most scientifically rigorous and translatable entry points for...
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0 Answers 0 Votes
Do we need quantum computers to develop treatment plans for tumors using artificial intelligence?
Do we truly need quantum computers to develop AI-driven treatment plans for tumors, or can classical computing—with better algorithms and hardware—still meet the challenge? Artificial intelligence is already being used in radiotherapy planning, drug regimen selection, and multi-omics prediction, but as models grow more complex and begin to integrate real-time imaging, genomic data, and spatiotemporal tumor dynamics, computational demands are rising sharply. Quantum computing is often proposed...
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0 Answers 0 Votes
Which is the main trigger molecule in the study of inflammatory cytokine storm?
Cytokine storm is a life-threatening hyperinflammatory response observed in infections, autoimmunity, and CAR-T therapy, and while molecules such as IL-6, TNF-α, IFN-γ, and HMGB1 are clearly involved, a fundamental debate remains: is there a single non-redundant master trigger molecule, or is cytokine storm inherently a network-driven phenomenon where multiple pathways activate in parallel and amplify each other through positive feedback loops with no single initiator? If you believe a master...
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6 Answers 2 Votes
Role of humanized immune system mice in to study the infectious and systemic inflammatory disease.
Whether the humanized immune system (HIS) mice help developing therapeutic interventions against infectious and inflammatory diseases? Whether HIS mice may revolutionize the translational biomedical research
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6 Answers 4 Votes
How might AI-assisted peer review tools reshape scientific publishing, and what safeguards should be implemented to maintain review quality while addressing the increasing volume of submissions?
The peer-reviewing process is being faced with ever-growing challenges as submission rates are still rising exponentially in all areas. Journal editors are faced with the challenge of getting capable reviewers who are ready to volunteer their time, with a result being delays in reviewing, reviewer exhaustion, and worse, compromised quality. Meanwhile, AI technologies are accelerating their ability to review scientific manuscripts for methodology, statistical fitting, plagiarism screenings,...
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4 Answers 0 Votes
What deep learning strategies best balance accuracy and interpretability in medical image segmentation for disease progression analysis?
Medical imaging (CT/MRI) segmentation is vital for tracking disease, but black-box models reduce clinical trust. Methods like explainable AI (XAI), uncertainty quantification, and hybrid modeling may bridge this gap. What approaches are most promising?
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5 Answers 1 Vote
For a change in the peer-reveiwing as an urgent need?
With an increasing number of Journal and other publication, the review by peer started to be difficult and very often nonqualified reviewers are solicited. Very often now the Journal send us a list that ressemble the directory a. This is a problem since many of the persons listed here do not have even a record over 10 and there are supposed to review works they don't know, and they are not qualified. I would like to start a huge discussion that can be sent to the main Journal to change the...
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14 Answers 2 Votes
Why is the death rate of male in heart disease always higher than that of women? How can a male achieve that power?
It is clear from the report of WHO that the death rate of Male in heart-disease is higher than that of women. This observation suggests that the woman may have some physical advantage. Besides, differential food, beverage-drinking, and smoking habit, etc. can also contribute to it. For example, the habit of consuming oily foods (saturated fat harms heart) is more in the case of some individuals (taste matter). Although many people are aware of the issue, they can't change the food-habits....
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0 Answers 0 Votes
In what way is fluence-dependent photobiomodulation at 660 nm modulating mitochondrial-driven motility and acrosomal membrane stability in human spermatozoa, and can a simulation-based model incorpora
This question integrates: Biophysical mechanisms (mitochondrial activity, acrosomal membrane) Photobiomodulation parameters (fluence, wavelength) Computational modeling (simulation-based, biological noise) Clinical translation (fertility optimization
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