Pings
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Answer Accepted 18 Answers 22 Votes
Could salary be used as a surrogate for smoking when sample data are lacking?
In epidemiology cohort studies, information on smoking status is often times lacking for the study sample, which makes it challenging to characterize the effects of other risk factors on endpoints that are causally related to smoking (e.g., lung cancer mortality). Given the strong inverse reported for smoking and income, could salary be used as a surrogate for smoking when direct data are lacking? or would potential relationships between salary other risk factors (e.g., health care access)...
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8 Answers 7 Votes
Do chronic studies in two species provide significant value in drug development?
Chronic studies in rodent (6 months) and non rodent (9 months) are required for approval of a new drug. Results of these studies are not required until the NDA is submitted, i.e. all the clinical trials are complete. The results of these studies are rarely included in the drug label. Since we generally have subchronic data in two species and long-term exposures in carcinogenicity studies, are the required chronic studies adding to patient safety?
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9 Answers 2 Votes
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5 Answers 1 Vote
How do carbon nanotubes prove beneficial in medical health care?
Nanotechnology in Medicine
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Answer Accepted 1 Answer 0 Votes
For me-too medical devices, on what basis should manufacturers choose biological tests to conduct?
Manufacturers producing a me-too medical device intended for implantation in the human body, conducting a full biocompatibility study including implantation effect that takes more than one year does not seem logical. With the availability of a reference medical device of the same material & intended use, how can the manufacturer choose the required biological tests?
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2 Answers 0 Votes
How should SciPinion improve their account profile page?
Currently, an account's profile includes a CV, education, employment. It also asks for an H-index but does not specify which source. It also excludes information about research output in general and limits itself seemingly to journal articles, chapters, and patents. It could ask about data sets, scientific software, and other research output forms. It can allow people to list an ORCID, ROR (institutes), Mastodon/Twitter, GitHub/GitLab accounts, etc, allowing people to establish a much richer...
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Answer Accepted 1 Answer 1 Vote
How the drug dosing space and therapeutic level in term of MTD may best be correlated with pharmacokinetics and body metabolic rate in the subject to gain best possible impact and to minimize the toxicity.
when we recommend the dose of antibiotics like oxytetracycline in animals we usually take into consideration the recommended dose on the label but most of the time the therapeutic effect may not be obtained as suspected. As physician we recommend little bit high dose of the drug in some animals for best results which becomes beyond the regulation authorities to justify. Is it possible to recommend the dosing space or dose of the drug flexible including some criteria of considering BMR of the...
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Complete 32 Answers 180 Votes
What questions would you like the SciPinion Community to address next in a SciPoll? $100
SciPinion is seeking your input for our upcoming SciPolls. Please participate in this SciPinion Ping (a single science-based question posted for other experts to answer) by posting your top multiple-choice question, including answer options. If you participate you will earn Ping credits to ask your own questions and if we choose your question, there is a $100 reward. We will choose at least one of the most popular and thought provoking questions. Please post your topic in the form of a...
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