Pings
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1 Answer 0 Votes
How can advancements in bioinformatics tools and multi-omics integration (genomics, transcriptomics, and proteomics) improve the early diagnosis of cancer in 2024?
How can bioinformatics tools optimize the integration of multi-omics data to identify highly specific and sensitive biomarkers for early cancer diagnosis? · What role does artificial intelligence play in analyzing complex biological datasets, and how can its predictions be validated for clinical use? · What challenges exist in the standardization of bioinformatics pipelines for regulatory approval and widespread clinical adoption? · How can researchers address issues such as data...
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8 Answers 7 Votes
Do chronic studies in two species provide significant value in drug development?
Chronic studies in rodent (6 months) and non rodent (9 months) are required for approval of a new drug. Results of these studies are not required until the NDA is submitted, i.e. all the clinical trials are complete. The results of these studies are rarely included in the drug label. Since we generally have subchronic data in two species and long-term exposures in carcinogenicity studies, are the required chronic studies adding to patient safety?
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3 Answers 3 Votes
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Answer Accepted 25 Answers 20 Votes
AI for academic writing: friend or foe?
Given the increasing availability of AI writing tools, how can academic institutions ensure the responsible use of these technologies while maintaining the integrity of research and scholarship?
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Answer Accepted 2 Answers 0 Votes
How can I keep bronchial epithelial cell alive, while retaining the effect of PM exposure?
Objective of the study: Evaluate whether normal bronchial epithelial cells acquire invasiveness following exposure to particulate matter. Initial approach: Expose the BEAS2B cell line to PM10 at concentrations of 50ug and 75ug for 48 hours. Subsequently, perform a wound healing assay and an invasion assay using matrigel. Problem encountered: Post exposure, a significant number of cells died, resulting in inadequate cell viability. This has hindered our ability to observe if the non-malignant...
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Answer Accepted 5 Answers 5 Votes
Why do cancer treatment options (chemotherapies + radiations) have outcome failure rates of 90% (+/-5) for solid tumors?
Despite seven decades of basic science, epidemiological and animal studies or clinical trials on cancer research and therapy, why cancer treatment options (chemotherapies + radiations) have outcome failure rates of 90% (+/-5) for solid tumors, according to governmental and private organizations. Please select your answer among the followings: 1. Need more research funding for epidemiological studies and experimental models of tumors and clinical trials. 2. Cancer is too many (100, 200...
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Answer Accepted 1 Answer 0 Votes
For me-too medical devices, on what basis should manufacturers choose biological tests to conduct?
Manufacturers producing a me-too medical device intended for implantation in the human body, conducting a full biocompatibility study including implantation effect that takes more than one year does not seem logical. With the availability of a reference medical device of the same material & intended use, how can the manufacturer choose the required biological tests?
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Answer Accepted 1 Answer 1 Vote
How the drug dosing space and therapeutic level in term of MTD may best be correlated with pharmacokinetics and body metabolic rate in the subject to gain best possible impact and to minimize the toxicity.
when we recommend the dose of antibiotics like oxytetracycline in animals we usually take into consideration the recommended dose on the label but most of the time the therapeutic effect may not be obtained as suspected. As physician we recommend little bit high dose of the drug in some animals for best results which becomes beyond the regulation authorities to justify. Is it possible to recommend the dosing space or dose of the drug flexible including some criteria of considering BMR of the...
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