Pings
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7 Answers 0 Votes
How long does it take for a glycoprotein to be synthesised de novo, processed in the ER/Golgi apparatus and transported to the cell membrane?
The trafficking time probably depends on the specific protein, but a ballpark average time is what I'm after. Please include references or examples.
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1 Answer 0 Votes
What is the most potential drug candidate in computer-aided drug design?
The drug-discovery process is highly costly and time-consuming. Thus, computer-aided drug design has become a very popular field and got applications. As the drug is used in human subjects, the protocol/technique/procedure to drug-design should be highly generalized and comprehensive. Generally high docking-scored drugs are considered best drug-candidates. I guess we should also check whether the best-scored drug satisfies any of the ADMET parameters. I think the optimum scored drug is...
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1 Answer 0 Votes
Is the role of ceramides in neurodegenerative diseases?
Ceramides, a class of lipid molecules, have been implicated in the pathogenesis of neurodegenerative diseases. Elevated levels of ceramides have been associated with cellular stress, inflammation, and apoptosis, which are processes involved in neurodegeneration. Researchers are investigating the specific mechanisms through which ceramides contribute to diseases like Alzheimer's and Parkinson's, aiming to understand their role and potential therapeutic interventions targeting ceramide pathways.
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5 Answers 1 Vote
How do carbon nanotubes prove beneficial in medical health care?
Nanotechnology in Medicine
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Answer Accepted 8 Answers 0 Votes
What is the relationship between free radicals and the inflammation process during Chronic diseases?
OxInflammation process is a complex and systemic event that occurs after cellular and tissue injury. The knowledge about both processes is that they coexist, but already known that possibly the inflammatory response is responsible for the generation of a pro-oxidative environment due to the production of Free radicals and Reactive Oxygen species (ROS), especially in chronic diseases. In normal tissue occurs the activation of efficient machinery able to control the oxidative stress, however,...
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Answer Accepted 2 Answers 1 Vote
Why we often observe quite different circadian rhythms, for example, for two plants growing in absolutely identical conditions?
Why we often observe quite different circadian rhythms, for example, for two plants growing in absolutely identical conditions?
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Answer Accepted 1 Answer 1 Vote
CryoEM: do you have any suggestion to concentrate samples after GRAFIX gradient?
After GRAFIX I am loosing all my sample on amicon filter.
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Answer Accepted 4 Answers 0 Votes
What is the best way to deplete resident macrophages in the heart?
I am planning studies that require depleting resident macrophages in the heart in a mouse model of myocardial infarction. There are multiple strategies including Csf1r and CD163 antibodies. What is the most specific and effective way to deplete resident cardiac macrophages?
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Answer Accepted 1 Answer 1 Vote
How the drug dosing space and therapeutic level in term of MTD may best be correlated with pharmacokinetics and body metabolic rate in the subject to gain best possible impact and to minimize the toxicity.
when we recommend the dose of antibiotics like oxytetracycline in animals we usually take into consideration the recommended dose on the label but most of the time the therapeutic effect may not be obtained as suspected. As physician we recommend little bit high dose of the drug in some animals for best results which becomes beyond the regulation authorities to justify. Is it possible to recommend the dosing space or dose of the drug flexible including some criteria of considering BMR of the...
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