Pings
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0 Answers 0 Votes
Are there any new biomarkers with clinical application potential for pancreatic cancer? Are there any new potentially exploitable molecules for predicting disease outcomes in the coming years?
Pancreatic ductal adenocarcinoma remains one of the most lethal malignancies, largely due to late diagnosis, profound heterogeneity, and resistance to conventional therapies. While CA19-9 remains the only widely used clinical biomarker, its limitations in sensitivity and specificity are well recognized. I would like to ask the gastroenterology, oncology, and translational research community: Which novel biomarker candidates—whether derived from liquid biopsy (ctDNA methylation, exosomal RNAs,...
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0 Answers 0 Votes
Hepatitis B treatment drug Roche's long-acting pegylated interferon alpha 2a is not currently sold in Chinese Mainland, how much impact will it have on Chinese patients?
Pegylated interferon alfa-2a (Pegasys) has long been a cornerstone of finite therapy for chronic hepatitis B, offering the potential for functional cure through immune modulation. However, the Roche formulation is no longer marketed or distributed in Mainland China, and although domestically developed pegylated interferons and standard interferons remain available, many clinicians report that the efficacy, tolerability, and HBsAg seroclearance rates associated with the original product are...
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0 Answers 0 Votes
What are the most popular directions in tumor immune research that can be linked to traditional Chinese medicine at present?
Traditional Chinese medicine has long been practiced in cancer care, yet its mechanistic interface with modern tumor immunology remains underexplored. Given the recent advances in immuno-oncology—particularly in areas such as gut microbiota modulation, tumor microenvironment reprogramming, metabolic reprogramming of immune cells, and reversal of T cell exhaustion—I am interested in identifying which of these frontiers offer the most scientifically rigorous and translatable entry points for...
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0 Answers 0 Votes
Do we need quantum computers to develop treatment plans for tumors using artificial intelligence?
Do we truly need quantum computers to develop AI-driven treatment plans for tumors, or can classical computing—with better algorithms and hardware—still meet the challenge? Artificial intelligence is already being used in radiotherapy planning, drug regimen selection, and multi-omics prediction, but as models grow more complex and begin to integrate real-time imaging, genomic data, and spatiotemporal tumor dynamics, computational demands are rising sharply. Quantum computing is often proposed...
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0 Answers 0 Votes
What is the single greatest bottleneck preventing the gradual transfer and upload of human consciousness via brain-computer interfaces?
This question sits at the intersection of neuroscience, computer science, and philosophy. While BCI technology has advanced in motor decoding and sensory feedback, the concept of “consciousness transfer” or “mind uploading” remains deeply speculative. I would like to ask the community: In your view, is the primary barrier fundamentally technological—such as the resolution limit of neural interface hardware, or our inability to map and simulate the ∼100 billion synapses in real time? Or is it...
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0 Answers 0 Votes
Which is the main trigger molecule in the study of inflammatory cytokine storm?
Cytokine storm is a life-threatening hyperinflammatory response observed in infections, autoimmunity, and CAR-T therapy, and while molecules such as IL-6, TNF-α, IFN-γ, and HMGB1 are clearly involved, a fundamental debate remains: is there a single non-redundant master trigger molecule, or is cytokine storm inherently a network-driven phenomenon where multiple pathways activate in parallel and amplify each other through positive feedback loops with no single initiator? If you believe a master...
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4 Answers 0 Votes
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
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5 Answers 0 Votes
How to examine for power of grip in a patient with weakness?
When we do clinical examination for weakness, power is ascertained by MRC grading. However, for grip, MRC grading cannot be used. Is there any method to examine hand grip power other than using dynamometer
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47 Answers 9 Votes
What are the biggest challenges facing your field of research?
1. Lack of funding 2. Difficulty in replicating studies 3. Difficulty in recruiting participants 4. Difficulty in obtaining necessary resources and equipment
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5 Answers 1 Vote
For a change in the peer-reveiwing as an urgent need?
With an increasing number of Journal and other publication, the review by peer started to be difficult and very often nonqualified reviewers are solicited. Very often now the Journal send us a list that ressemble the directory a. This is a problem since many of the persons listed here do not have even a record over 10 and there are supposed to review works they don't know, and they are not qualified. I would like to start a huge discussion that can be sent to the main Journal to change the...
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