Pings
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7 Answers 3 Votes
For a change in the peer-reveiwing as an urgent need?
With an increasing number of Journal and other publication, the review by peer started to be difficult and very often nonqualified reviewers are solicited. Very often now the Journal send us a list that ressemble the directory a. This is a problem since many of the persons listed here do not have even a record over 10 and there are supposed to review works they don't know, and they are not qualified. I would like to start a huge discussion that can be sent to the main Journal to change the...
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Answer Accepted 10 Answers 13 Votes
Can pesticides penetrate into fruits and vegetables as well as on their surface? Is it possible to completely remove pesticide residue?
Can pesticides penetrate not only the outside but also the inside of vegetables and fruits? How to remove pesticide residue from the surface? Is it possible to completely remove pesticide residue?
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0 Answers 0 Votes
What are the key immune mechanisms underlying transplant tolerance, and which novel strategies show promise for clinically safe rejection prevention?
Despite the continuous progress of immunosuppressants, long-term transplant rejection and drug toxicity remain major challenges. Transplant tolerance (a donor specific immune non responsive state that does not rely on sustained immune suppression) remains a difficult goal to achieve. The key mechanisms include central and peripheral immune regulation (such as regulatory T cells, immune exhaustion, clonal clearance, myeloid suppressor cells, etc.). The new strategies include co stimulatory...
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6 Answers 2 Votes
Role of humanized immune system mice in to study the infectious and systemic inflammatory disease.
Whether the humanized immune system (HIS) mice help developing therapeutic interventions against infectious and inflammatory diseases? Whether HIS mice may revolutionize the translational biomedical research
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Answer Accepted 1 Answer 0 Votes
What is the current research progress on the role of the JAK/STAT/mTOR pathway in liver inflammation during liver failure, and is it considered a core pathway in this process?
I am studying the regulatory network of liver inflammation in the pathogenesis of liver failure, especially acute‑on‑chronic liver failure (ACLF). My current focus is on the phosphorylation activation of the JAK/STAT pathway and its downstream mTOR signaling in mediating hepatocyte death, macrophage polarization, and the inflammatory storm. I would like to know the latest research progress on this pathway—for example, whether it involves intercellular crosstalk—and whether the JAK/STAT/mTOR...
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Answer Accepted 10 Answers 6 Votes
No threshold approach in the risk assessment of genotoxic carcinogen. Is it still well supported by current knowledge of carcinogenesis?
No threshold approach is routinely applied in the risk assessment of genotoxic carcinogens. How this approach is supported by data? Isn´ t it somewhat obsolete?
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6 Answers 5 Votes
How should exposure durations be scaled from studies in mice and rats to humans?
Time-Scaling for Developmental Toxicity Endpoints How should exposure durations be scaled from studies in mice and rats to humans? Is a 10-day rodent exposure equivalent to a 10-day human exposure during gestation?
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6 Answers 2 Votes
When the policy exists to share postprints freely on personal sites, why do researchers often refrain from doing so, and what incentives or constraints drive that hesitation?
There has been extensive discussion about the funding model for research publications. Large publishing houses do not fund research themselves; instead, they charge substantial subscription fees or open-access publishing fees. Keeping articles behind paywalls can impede open science and broad access to knowledge. Nevertheless, many publishers grant authors the right to share postprints of their papers immediately on their non-commercial personal blogs or websites. Despite this permission,...
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4 Answers 0 Votes
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
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2 Answers 0 Votes
Why is the ammonia/ammonium concentration highly increased during storage of human urine?
Hydrolysis of urine Why is the ammonia/ammonium concentration highly increased during storage of human urine?
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