Pings
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9 Answers 13 Votes
Can pesticides penetrate into fruits and vegetables as well as on their surface? Is it possible to completely remove pesticide residue?
Can pesticides penetrate not only the outside but also the inside of vegetables and fruits? How to remove pesticide residue from the surface? Is it possible to completely remove pesticide residue?
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4 Answers 0 Votes
What threshold of urinary cadmium (Cd-U) is currently considered indicative of early renal tubular dysfunction in exposed adult populations?
I am conducting a study on chronic environmental cadmium exposure and its nephrotoxic effects, particularly focusing on early biomarkers of renal tubular damage. Several sources suggest 2 µg/g creatinine as a reference point, but variability exists depending on population, sex, and co-exposure. Could experts clarify which threshold (e.g. 1 µg/g, 2 µg/g, or 5 µg/g creatinine) is most reliable or currently used in risk assessments and clinical practice?
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6 Answers 0 Votes
No threshold approach in the risk assessment of genotoxic carcinogen. Is it still well supported by current knowledge of carcinogenesis?
No threshold approach is routinely applied in the risk assessment of genotoxic carcinogens. How this approach is supported by data? Isn´ t it somewhat obsolete?
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Answer Accepted 2 Answers 0 Votes
Does Yoghurt, Cheese and Milk consumption reduce gut gram negative bacteria and toxic plasma bacterial lipopolysaccharides?
RELEVANT REFERENCES: 1. Sharma, A and IJ Martins. The role of Microbiota in the pathogenesis of Alzheimer’s disease. Acta Scientific Nutritional Health. 7.7 (2023): 108-118. 2. Bacterial Lipopolysaccharides and Neuron Toxicity in Neurodegenerative Diseases. Neurology Research and Surgery. 2018; 1(1): 1-3. 3. Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. Int J Mol Sci. 201516(12): 29554–29573.
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Answer Accepted 1 Answer 0 Votes
Do various CLINICIANS need to monitor Sirtuin 1 gene expression and plasma Sirtuin 1 levels with relevance to various drug therapies in patients?
Specific genes that are involved in anti-aging and epigenetics are sensitive to nutritional regulation, oxidative stress and the development of insulin resistance that can result from changes in cellular chromatin, DNA methylation and histone modifications with relevance to the global chronic disease epidemic. The defective gene in the global chronic disease epidemic has now been linked to the anti-aging gene Sirtuin 1. Nutritional regulation of Sirtuin 1 is critical to nuclear...
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Answer Accepted 2 Answers 0 Votes
Does Yoghurt, Cheese and Milk consumption reduce gut gram negative bacteria and toxic plasma bacterial lipopolysaccharides?
RELEVANT REFERENCES: 1. Sharma, A and IJ Martins. The role of Microbiota in the pathogenesis of Alzheimer’s disease. Acta Scientific Nutritional Health. 7.7 (2023): 108-118. 2. Bacterial Lipopolysaccharides and Neuron Toxicity in Neurodegenerative Diseases. Neurology Research and Surgery. 2018; 1(1): 1-3. 3. Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. Int J Mol Sci. 201516(12): 29554–29573.
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Answer Accepted 2 Answers 1 Vote
Can phytoestrogens slow down aging in women?
Phytoestrogens are a variety of nonsteroidal compounds of plants which are similar to estradiol. They have both anti-estrogenic and estrogen-like effects. It is known that phytoestrogens normalize the condition of the body of women with menopausal syndrome. However, can they compensate for estrogen deficiency and reduce the rate of aging?
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6 Answers 1 Vote
I'm wondering, if the EDC such as bisphenol A, was chlorinated during the water treatment process, is the toxicity of formed disinfection by-products (DBPs) from EDCs smaller than the EDCs itself?
Many studies have been conducted on the DBP formation potential of endocrine-disrupting chemicals (EDC), however, the toxicity comparison (before and after the chlorination process) was not comprehensive and limited.
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18 Answers 8 Votes
Is Oxidative Stress sufficient by itself as an indicator and compelling basis for a carcinogenic concern?
Oxidative Stress as a Precursor and Mechanism for Carcinogenicity IARC and others (Smith et al) have identified 10 key characteristics which may be used/considered in the evaluation of carcinogenicity, one of which is oxidative stress. How strong or compelling, if at all, would the data need to be for considering OS as a putative and defensible MOA for carcinogenicity, or would there need to be other tangential/correlative data (e.g., tumors) available. In other words, is OS sufficient by...
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Answer Accepted 8 Answers 0 Votes
What is the relationship between free radicals and the inflammation process during Chronic diseases?
OxInflammation process is a complex and systemic event that occurs after cellular and tissue injury. The knowledge about both processes is that they coexist, but already known that possibly the inflammatory response is responsible for the generation of a pro-oxidative environment due to the production of Free radicals and Reactive Oxygen species (ROS), especially in chronic diseases. In normal tissue occurs the activation of efficient machinery able to control the oxidative stress, however,...
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