Pings
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6 Answers 5 Votes
How should exposure durations be scaled from studies in mice and rats to humans?
Time-Scaling for Developmental Toxicity Endpoints How should exposure durations be scaled from studies in mice and rats to humans? Is a 10-day rodent exposure equivalent to a 10-day human exposure during gestation?
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4 Answers 0 Votes
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
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6 Answers 1 Vote
For a change in the peer-reveiwing as an urgent need?
With an increasing number of Journal and other publication, the review by peer started to be difficult and very often nonqualified reviewers are solicited. Very often now the Journal send us a list that ressemble the directory a. This is a problem since many of the persons listed here do not have even a record over 10 and there are supposed to review works they don't know, and they are not qualified. I would like to start a huge discussion that can be sent to the main Journal to change the...
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Answer Accepted 1 Answer 1 Vote
What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?
Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?
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9 Answers 13 Votes
Can pesticides penetrate into fruits and vegetables as well as on their surface? Is it possible to completely remove pesticide residue?
Can pesticides penetrate not only the outside but also the inside of vegetables and fruits? How to remove pesticide residue from the surface? Is it possible to completely remove pesticide residue?
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Answer Accepted 1 Answer 0 Votes
Do various CLINICIANS need to monitor Sirtuin 1 gene expression and plasma Sirtuin 1 levels with relevance to various drug therapies in patients?
Specific genes that are involved in anti-aging and epigenetics are sensitive to nutritional regulation, oxidative stress and the development of insulin resistance that can result from changes in cellular chromatin, DNA methylation and histone modifications with relevance to the global chronic disease epidemic. The defective gene in the global chronic disease epidemic has now been linked to the anti-aging gene Sirtuin 1. Nutritional regulation of Sirtuin 1 is critical to nuclear...
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Answer Accepted 2 Answers 0 Votes
In developing bioresorbable metallic implants for bone applications, what do you think are the biggest challenges?
Presently, a lot of research is going on based on magnesium, zinc, and iron for being used as temporary implants for orthopedic applications. Despite its advantages, widespread adoption in clinical settings still presents numerous challenges.
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7 Answers 3 Votes
What is the most important research material in protein bioinformatics? 1. Protein sequence 2. Protein structure 3. Protein-related Software 4. A high-speed computer
A protein's sequence contains its intrinsic properties as a code. Nobel laureate scientist, C. B. Anfinsen proved it through experiments. Unlike sequence, since structures are man-made and obtained under different laboratory conditions, they may contain human error. Further, unlike nucleic acid, to date, the protein-folding code is unknown. So, in my opinion the study of protein sequence is primary. It is better if one can include structure study with it. But little can be said about this...
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Answer Accepted 15 Answers 13 Votes
Snail mucous has many advantages, what is the best way to extract it without changing its composition?
land snails like Eremina desertorum, how can i get its mucous without killing or hurting it?
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Answer Accepted 2 Answers 1 Vote
Can phytoestrogens slow down aging in women?
Phytoestrogens are a variety of nonsteroidal compounds of plants which are similar to estradiol. They have both anti-estrogenic and estrogen-like effects. It is known that phytoestrogens normalize the condition of the body of women with menopausal syndrome. However, can they compensate for estrogen deficiency and reduce the rate of aging?
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