Pings
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7 Answers 3 Votes
For a change in the peer-reveiwing as an urgent need?
With an increasing number of Journal and other publication, the review by peer started to be difficult and very often nonqualified reviewers are solicited. Very often now the Journal send us a list that ressemble the directory a. This is a problem since many of the persons listed here do not have even a record over 10 and there are supposed to review works they don't know, and they are not qualified. I would like to start a huge discussion that can be sent to the main Journal to change the...
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0 Answers 0 Votes
What are the key immune mechanisms underlying transplant tolerance, and which novel strategies show promise for clinically safe rejection prevention?
Despite the continuous progress of immunosuppressants, long-term transplant rejection and drug toxicity remain major challenges. Transplant tolerance (a donor specific immune non responsive state that does not rely on sustained immune suppression) remains a difficult goal to achieve. The key mechanisms include central and peripheral immune regulation (such as regulatory T cells, immune exhaustion, clonal clearance, myeloid suppressor cells, etc.). The new strategies include co stimulatory...
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3 Answers 0 Votes
How can advances in electrochemical CO₂ conversion improve scalability of carbon-to-fuel technologies while minimizing energy demand and byproduct formation?
As a specialist in CO₂ reduction, my work focuses on advancing pathways that move beyond capture and storage toward scalable, value-added solutions. Current approaches including mineralization, electrochemical conversion, and bio-catalytic processes show potential but face challenges of efficiency, energy demand, and long-term stability. A critical next step is identifying how chemical, mineral, or catalytic enhancements can accelerate these processes while maintaining sustainability and...
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1 Answer 0 Votes
. Is there a test that utilises anti-PSA monoclonal antibodies to localise PSA-avid tumour in the body?
The issue of a persistently rising Prostatic Surface Antigen (PSA) level in blood post prostatectomy for cancer of the prostate remains problematic in clinical practice especially in patients without evidence of local recurrence or metastatic disease on MRI/PET Scan.
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6 Answers 2 Votes
Role of humanized immune system mice in to study the infectious and systemic inflammatory disease.
Whether the humanized immune system (HIS) mice help developing therapeutic interventions against infectious and inflammatory diseases? Whether HIS mice may revolutionize the translational biomedical research
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3 Answers 0 Votes
What are recent machanism of actions, minmum duration of years of heat exposure and minimum temperature required for various heat induced skin cancers, also opnion for Kangri Cancer to be answered
There are various heat induced cancers in world.Duration of exposure,minmum temperature required for inducing pre-malignant changes, sites of cancers are uner review. Mechanism of action is important in these cases Anyone having more knowledge of mechanism of action for Kangri Cancer or other heat induced cancers
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Answer Accepted 1 Answer 0 Votes
How does STAT3 contribute to intestinal mucosal barrier function, particularly during mucosal repair after injury?
Elucidating the role of STAT3 in intestinal epithelial regeneration and barrier integrity is critical for understanding IBD pathogenesis and tissue recovery. Key aspects include: 1.Epithelial-specific vs. immune-cell STAT3 signaling in wound healingDownstream targets (e.g., mucins, 2.tight junction proteins) mediating barrier protectionContext-dependent effects: protective versus pro-inflammatory roles 3.Insights could inform therapeutic strategies for mucosal healing. Relevant diagrams or...
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Answer Accepted 10 Answers 6 Votes
No threshold approach in the risk assessment of genotoxic carcinogen. Is it still well supported by current knowledge of carcinogenesis?
No threshold approach is routinely applied in the risk assessment of genotoxic carcinogens. How this approach is supported by data? Isn´ t it somewhat obsolete?
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4 Answers 3 Votes
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4 Answers 0 Votes
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
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