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6 Answers 0 Votes
How to examine for power of grip in a patient with weakness?
When we do clinical examination for weakness, power is ascertained by MRC grading. However, for grip, MRC grading cannot be used. Is there any method to examine hand grip power other than using dynamometer
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4 Answers 0 Votes
In austere/conflict settings, when does a complex surgery become ethically unjustifiable due to a lack of postoperative resources for managing complications?
As surgeons, we are trained to operate to solve a clinical problem. However, in severely resource-limited or conflict environments, this principle is constantly tested. Consider a scenario: A surgeon has the technical skill to perform a complex procedure (e.g., a pancreaticoduodenectomy for a tumor, or a complex limb salvage after trauma). However, the hospital lacks a reliable ICU, has inconsistent access to blood products, cannot provide parenteral nutrition, and has limited options for...
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Answer Accepted 1 Answer 0 Votes
What is the current research progress on the role of the JAK/STAT/mTOR pathway in liver inflammation during liver failure, and is it considered a core pathway in this process?
I am studying the regulatory network of liver inflammation in the pathogenesis of liver failure, especially acute‑on‑chronic liver failure (ACLF). My current focus is on the phosphorylation activation of the JAK/STAT pathway and its downstream mTOR signaling in mediating hepatocyte death, macrophage polarization, and the inflammatory storm. I would like to know the latest research progress on this pathway—for example, whether it involves intercellular crosstalk—and whether the JAK/STAT/mTOR...
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4 Answers 0 Votes
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
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Answer Accepted 2 Answers 0 Votes
Artificial intelligence has brought great hope to advancing our understanding of severe inflammation by simulating complex signal networks and molecular mechanisms that determine disease trajectories.
Artificial intelligence has brought great hope to advancing our understanding of severe inflammation by simulating complex signal networks and molecular mechanisms that determine disease trajectories. The core of this work is pathways such as NF - κ B, MAPK, and JAK-STAT, which regulate the expression of pro-inflammatory cytokines and mediators. These pathways are regulated by post-translational modifications, transcription factor dynamics, and crosstalk with damage associated molecular...
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25 Answers 54 Votes
For respiratory viruses, should folks wear masks in public a) always, b) if they are or may be infected, or c) if they are afraid of getting infected? Are masks a) protection, or b) social signals?
Since 2020, the public has thought of masks as having a protective purpose, and many rebel at the inconvenience, rationalizing that “they do a poor job of protecting.” Is the current epidemic a good opportunity for government and medicine to teach the folks about the more important virtues of using masks to convey information?
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Answer Accepted 1 Answer 1 Vote
What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?
Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?
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4 Answers 2 Votes
Why are ambitious, planet-critical research proposals, still hitting funding roadblocks, and what will it take to break down these barriers before it’s too late?
Why are we underfunding high-impact climate solutions despite escalating risks—and what funding models would actually move the needle?
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2 Answers 0 Votes
what are the possible side effects of the use of 5 alpha reductase inhibitors in young men?
what is the incidence of side effects? what are the common side effects and symptoms? what are the genetics and molecular bases for such side effects and symptoms?
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Answer Accepted 1 Answer 1 Vote
Assuming your role involves human health, how do you identify those medical practitioners of expertise when you suggest a consultant for your patient?
There is a difference in the skill of physicians to whom we entrust lives. This quotation has relevance to such a dilemma: "What do you call the medical student who graduates first in his class? —-"Doctor" "And what do you call the med student who graduates last in his class? — "Doctor" [Image]
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