Pings
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7 Answers 3 Votes
For a change in the peer-reveiwing as an urgent need?
With an increasing number of Journal and other publication, the review by peer started to be difficult and very often nonqualified reviewers are solicited. Very often now the Journal send us a list that ressemble the directory a. This is a problem since many of the persons listed here do not have even a record over 10 and there are supposed to review works they don't know, and they are not qualified. I would like to start a huge discussion that can be sent to the main Journal to change the...
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0 Answers 0 Votes
What are the key immune mechanisms underlying transplant tolerance, and which novel strategies show promise for clinically safe rejection prevention?
Despite the continuous progress of immunosuppressants, long-term transplant rejection and drug toxicity remain major challenges. Transplant tolerance (a donor specific immune non responsive state that does not rely on sustained immune suppression) remains a difficult goal to achieve. The key mechanisms include central and peripheral immune regulation (such as regulatory T cells, immune exhaustion, clonal clearance, myeloid suppressor cells, etc.). The new strategies include co stimulatory...
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Answer Accepted 1 Answer 0 Votes
What is the current research progress on the role of the JAK/STAT/mTOR pathway in liver inflammation during liver failure, and is it considered a core pathway in this process?
I am studying the regulatory network of liver inflammation in the pathogenesis of liver failure, especially acute‑on‑chronic liver failure (ACLF). My current focus is on the phosphorylation activation of the JAK/STAT pathway and its downstream mTOR signaling in mediating hepatocyte death, macrophage polarization, and the inflammatory storm. I would like to know the latest research progress on this pathway—for example, whether it involves intercellular crosstalk—and whether the JAK/STAT/mTOR...
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6 Answers 2 Votes
When the policy exists to share postprints freely on personal sites, why do researchers often refrain from doing so, and what incentives or constraints drive that hesitation?
There has been extensive discussion about the funding model for research publications. Large publishing houses do not fund research themselves; instead, they charge substantial subscription fees or open-access publishing fees. Keeping articles behind paywalls can impede open science and broad access to knowledge. Nevertheless, many publishers grant authors the right to share postprints of their papers immediately on their non-commercial personal blogs or websites. Despite this permission,...
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4 Answers 0 Votes
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
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Answer Accepted 1 Answer 1 Vote
What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?
Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?
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Answer Accepted 6 Answers 7 Votes
Do recurring evaluations by research funders genuinely enhance research quality and societal impact, or do they merely create unnecessary administrative burdens?
Many research funders require periodic evaluations of projects to ensure accountability, monitor progress, and assess impact. While such evaluations can drive improvements in research design, transparency, and relevance, they can also consume significant time and resources. This raises the question of whether the benefits—such as higher-quality outputs and stronger societal contributions—outweigh the potential drawbacks, including administrative overload and reduced time for actual research.
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3 Answers 1 Vote
How many samples do you need to analyze for effective blood plasma products quality control?
A blood bank is set up with a laboratory for the preparation of blood components. Product quality control (e.g. plasma sterility) should be performed. How many samples do you need to analyze for effective control? How do you calculate this number? Does it vary depending on the total number of components produced?
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Answer Accepted 1 Answer 0 Votes
When turning at intersections, how difficult do you find it to detect pedestrians on the crosswalk? And how helpful do you think visual or sound warnings (like lights or beeps) would be?
Turning at intersections presents a common challenge for drivers, especially when pedestrians are crossing from the left or right side. Detecting pedestrians in these situations can be difficult due to blind spots, A-pillar obstruction, distractions, and poor visibility (e.g., nighttime, fog, or busy environments). To enhance safety, researchers and manufacturers are exploring pedestrian warning systems that use visual (e.g., LED lights) and auditory (e.g., beep sounds) alerts to help drivers...
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Answer Accepted 2 Answers 0 Votes
In developing bioresorbable metallic implants for bone applications, what do you think are the biggest challenges?
Presently, a lot of research is going on based on magnesium, zinc, and iron for being used as temporary implants for orthopedic applications. Despite its advantages, widespread adoption in clinical settings still presents numerous challenges.
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