Pings
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3 Answers 1 Vote
Role of humanized immune system mice in to study the infectious and systemic inflammatory disease.
Whether the humanized immune system (HIS) mice help developing therapeutic interventions against infectious and inflammatory diseases? Whether HIS mice may revolutionize the translational biomedical research
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Answer Accepted 3 Answers 3 Votes
Could the significantly increase in childhood diseases be associated with drug abuse and government (CDC) mandates for over-vaccination of public with pathogen-specific vaccines?
Overview of data on American health status (young and old) and the tremendous cost of healthcare (sick care, drug-dependency and hospitalization) provides compelling evidence that in the twentieth century nearly all classic disease categories (congenital, inherited, neonatal, or induced) that occurred at the rates of 2 to 5 % in the last century, shifted to increase induced diseases (at rates as high as 50 % or more), according to official reports by governmental agencies and private...
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2 Answers 0 Votes
For a change in the peer-reveiwing as an urgent need?
With an increasing number of Journal and other publication, the review by peer started to be difficult and very often nonqualified reviewers are solicited. Very often now the Journal send us a list that ressemble the directory a. This is a problem since many of the persons listed here do not have even a record over 10 and there are supposed to review works they don't know, and they are not qualified. I would like to start a huge discussion that can be sent to the main Journal to change the...
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1 Answer 0 Votes
Rheumatoid Arthritis affects around 18 million people globally and has no known cure. DMARDs help control symptoms but don’t cure the disease. What traditional remedies are used for RA in your area?
Rheumatoid Arthritis is currently a globally prevalent condition, affecting around 18 million people, with no known curative treatment. Although Disease-Modifying Anti-Rheumatic Drugs (DMARDs) are widely used and often well-tolerated, they only control symptoms and progressions not cure the disease. In many communities, including mine, various traditional treatments such as herbal remedies with best outcome, have been tried. What traditional or community-based treatments have you seen or...
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2 Answers 0 Votes
What are the potentials and ethical challenges that CRISPR-Cas9 technology is opening up in modern medicine?
CRISPR-Cas9, a revolutionary gene-editing tool, allows scientists to precisely cut and paste DNA sequences. This capability opens vast possibilities for medicine, but also brings significant ethical dilemmas.
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11 Answers 5 Votes
How to quickly check the purity of primary cultures of neurons
Any quick method to test purity of primary cultures of neurons (after 17 days of culture, right before using them for signaling assays)?
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12 Answers 3 Votes
Any herbal medicines used for hepatitis, possible mechanism of action, and if possible attached pictures of plants with citations
Any herbal medicines used for hepatitis, possible mechanism of action, and if possible attached pictures of plants with citations
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7 Answers 0 Votes
How long does it take for a glycoprotein to be synthesised de novo, processed in the ER/Golgi apparatus and transported to the cell membrane?
The trafficking time probably depends on the specific protein, but a ballpark average time is what I'm after. Please include references or examples.
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Answer Accepted 8 Answers 0 Votes
What is the relationship between free radicals and the inflammation process during Chronic diseases?
OxInflammation process is a complex and systemic event that occurs after cellular and tissue injury. The knowledge about both processes is that they coexist, but already known that possibly the inflammatory response is responsible for the generation of a pro-oxidative environment due to the production of Free radicals and Reactive Oxygen species (ROS), especially in chronic diseases. In normal tissue occurs the activation of efficient machinery able to control the oxidative stress, however,...
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Answer Accepted 4 Answers 0 Votes
What is the best way to deplete resident macrophages in the heart?
I am planning studies that require depleting resident macrophages in the heart in a mouse model of myocardial infarction. There are multiple strategies including Csf1r and CD163 antibodies. What is the most specific and effective way to deplete resident cardiac macrophages?
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