Pings
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2 Answers 0 Votes
Which impact has Bempedoic Acid on atherosclrosis plaque stability ?
Mechanism of action
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Answer Accepted 2 Answers 0 Votes
Does Yoghurt, Cheese and Milk consumption reduce gut gram negative bacteria and toxic plasma bacterial lipopolysaccharides?
RELEVANT REFERENCES: 1. Sharma, A and IJ Martins. The role of Microbiota in the pathogenesis of Alzheimer’s disease. Acta Scientific Nutritional Health. 7.7 (2023): 108-118. 2. Bacterial Lipopolysaccharides and Neuron Toxicity in Neurodegenerative Diseases. Neurology Research and Surgery. 2018; 1(1): 1-3. 3. Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. Int J Mol Sci. 201516(12): 29554–29573.
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3 Answers 1 Vote
How many samples do you need to analyze for effective blood plasma products quality control?
A blood bank is set up with a laboratory for the preparation of blood components. Product quality control (e.g. plasma sterility) should be performed. How many samples do you need to analyze for effective control? How do you calculate this number? Does it vary depending on the total number of components produced?
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0 Answers 0 Votes
. Is there a test that utilises anti-PSA monoclonal antibodies to localise PSA-avid tumour in the body?
The issue of a persistently rising Prostatic Surface Antigen (PSA) level in blood post prostatectomy for cancer of the prostate remains problematic in clinical practice especially in patients without evidence of local recurrence or metastatic disease on MRI/PET Scan.
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Answer Accepted 2 Answers 0 Votes
Does Yoghurt, Cheese and Milk consumption reduce gut gram negative bacteria and toxic plasma bacterial lipopolysaccharides?
RELEVANT REFERENCES: 1. Sharma, A and IJ Martins. The role of Microbiota in the pathogenesis of Alzheimer’s disease. Acta Scientific Nutritional Health. 7.7 (2023): 108-118. 2. Bacterial Lipopolysaccharides and Neuron Toxicity in Neurodegenerative Diseases. Neurology Research and Surgery. 2018; 1(1): 1-3. 3. Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. Int J Mol Sci. 201516(12): 29554–29573.
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Answer Accepted 1 Answer 0 Votes
What is the level of study with the highest level of scientific evidence in the health area?
1️⃣ Individual-level meta-analysis – Reanalyzes raw data from multiple studies for more accurate answers. 2️⃣ Network meta-analysis – Connects treatments that have never been directly compared, ranking their effectiveness. 3️⃣ Dose-response meta-analysis – Reveals the impact of different doses on clinical outcomes.
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Answer Accepted 18 Answers 22 Votes
Could salary be used as a surrogate for smoking when sample data are lacking?
In epidemiology cohort studies, information on smoking status is often times lacking for the study sample, which makes it challenging to characterize the effects of other risk factors on endpoints that are causally related to smoking (e.g., lung cancer mortality). Given the strong inverse reported for smoking and income, could salary be used as a surrogate for smoking when direct data are lacking? or would potential relationships between salary other risk factors (e.g., health care access)...
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1 Answer 0 Votes
How can advancements in bioinformatics tools and multi-omics integration (genomics, transcriptomics, and proteomics) improve the early diagnosis of cancer in 2024?
How can bioinformatics tools optimize the integration of multi-omics data to identify highly specific and sensitive biomarkers for early cancer diagnosis? · What role does artificial intelligence play in analyzing complex biological datasets, and how can its predictions be validated for clinical use? · What challenges exist in the standardization of bioinformatics pipelines for regulatory approval and widespread clinical adoption? · How can researchers address issues such as data...
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8 Answers 7 Votes
Do chronic studies in two species provide significant value in drug development?
Chronic studies in rodent (6 months) and non rodent (9 months) are required for approval of a new drug. Results of these studies are not required until the NDA is submitted, i.e. all the clinical trials are complete. The results of these studies are rarely included in the drug label. Since we generally have subchronic data in two species and long-term exposures in carcinogenicity studies, are the required chronic studies adding to patient safety?
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3 Answers 3 Votes
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