Pings
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0 Answers 0 Votes
What are the key immune mechanisms underlying transplant tolerance, and which novel strategies show promise for clinically safe rejection prevention?
Despite the continuous progress of immunosuppressants, long-term transplant rejection and drug toxicity remain major challenges. Transplant tolerance (a donor specific immune non responsive state that does not rely on sustained immune suppression) remains a difficult goal to achieve. The key mechanisms include central and peripheral immune regulation (such as regulatory T cells, immune exhaustion, clonal clearance, myeloid suppressor cells, etc.). The new strategies include co stimulatory...
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1 Answer 0 Votes
. Is there a test that utilises anti-PSA monoclonal antibodies to localise PSA-avid tumour in the body?
The issue of a persistently rising Prostatic Surface Antigen (PSA) level in blood post prostatectomy for cancer of the prostate remains problematic in clinical practice especially in patients without evidence of local recurrence or metastatic disease on MRI/PET Scan.
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6 Answers 2 Votes
Role of humanized immune system mice in to study the infectious and systemic inflammatory disease.
Whether the humanized immune system (HIS) mice help developing therapeutic interventions against infectious and inflammatory diseases? Whether HIS mice may revolutionize the translational biomedical research
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Answer Accepted 1 Answer 0 Votes
What is the current research progress on the role of the JAK/STAT/mTOR pathway in liver inflammation during liver failure, and is it considered a core pathway in this process?
I am studying the regulatory network of liver inflammation in the pathogenesis of liver failure, especially acute‑on‑chronic liver failure (ACLF). My current focus is on the phosphorylation activation of the JAK/STAT pathway and its downstream mTOR signaling in mediating hepatocyte death, macrophage polarization, and the inflammatory storm. I would like to know the latest research progress on this pathway—for example, whether it involves intercellular crosstalk—and whether the JAK/STAT/mTOR...
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3 Answers 0 Votes
What are recent machanism of actions, minmum duration of years of heat exposure and minimum temperature required for various heat induced skin cancers, also opnion for Kangri Cancer to be answered
There are various heat induced cancers in world.Duration of exposure,minmum temperature required for inducing pre-malignant changes, sites of cancers are uner review. Mechanism of action is important in these cases Anyone having more knowledge of mechanism of action for Kangri Cancer or other heat induced cancers
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Answer Accepted 1 Answer 0 Votes
How does STAT3 contribute to intestinal mucosal barrier function, particularly during mucosal repair after injury?
Elucidating the role of STAT3 in intestinal epithelial regeneration and barrier integrity is critical for understanding IBD pathogenesis and tissue recovery. Key aspects include: 1.Epithelial-specific vs. immune-cell STAT3 signaling in wound healingDownstream targets (e.g., mucins, 2.tight junction proteins) mediating barrier protectionContext-dependent effects: protective versus pro-inflammatory roles 3.Insights could inform therapeutic strategies for mucosal healing. Relevant diagrams or...
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4 Answers 3 Votes
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Answer Accepted 2 Answers 0 Votes
Artificial intelligence has brought great hope to advancing our understanding of severe inflammation by simulating complex signal networks and molecular mechanisms that determine disease trajectories.
Artificial intelligence has brought great hope to advancing our understanding of severe inflammation by simulating complex signal networks and molecular mechanisms that determine disease trajectories. The core of this work is pathways such as NF - κ B, MAPK, and JAK-STAT, which regulate the expression of pro-inflammatory cytokines and mediators. These pathways are regulated by post-translational modifications, transcription factor dynamics, and crosstalk with damage associated molecular...
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Answer Accepted 2 Answers 0 Votes
What can be expected from the development of preventive vaccines for non virally-induced cancers?
The introduction of prophylactic vaccines for virally-induced cancers (primarily HBV and HPV) has achieved a tremendous impact on disease related deaths. This has, in time, raised interest in developing vaccines to intercept pre-cancerous cells based on their expression of aberrant self-antigens (e.g. hypoglycosilated MUC1 in colon, lung and breast carcinomas). As of 2024, a number of phase I clinical studies have been ongoing in the USA, for both primary prevention and early cancer...
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Answer Accepted 1 Answer 1 Vote
What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?
Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?
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