Pings
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0 Answers 0 Votes
What are the key immune mechanisms underlying transplant tolerance, and which novel strategies show promise for clinically safe rejection prevention?
Despite the continuous progress of immunosuppressants, long-term transplant rejection and drug toxicity remain major challenges. Transplant tolerance (a donor specific immune non responsive state that does not rely on sustained immune suppression) remains a difficult goal to achieve. The key mechanisms include central and peripheral immune regulation (such as regulatory T cells, immune exhaustion, clonal clearance, myeloid suppressor cells, etc.). The new strategies include co stimulatory...
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1 Answer 0 Votes
. Is there a test that utilises anti-PSA monoclonal antibodies to localise PSA-avid tumour in the body?
The issue of a persistently rising Prostatic Surface Antigen (PSA) level in blood post prostatectomy for cancer of the prostate remains problematic in clinical practice especially in patients without evidence of local recurrence or metastatic disease on MRI/PET Scan.
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4 Answers 0 Votes
In austere/conflict settings, when does a complex surgery become ethically unjustifiable due to a lack of postoperative resources for managing complications?
As surgeons, we are trained to operate to solve a clinical problem. However, in severely resource-limited or conflict environments, this principle is constantly tested. Consider a scenario: A surgeon has the technical skill to perform a complex procedure (e.g., a pancreaticoduodenectomy for a tumor, or a complex limb salvage after trauma). However, the hospital lacks a reliable ICU, has inconsistent access to blood products, cannot provide parenteral nutrition, and has limited options for...
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3 Answers 0 Votes
What are recent machanism of actions, minmum duration of years of heat exposure and minimum temperature required for various heat induced skin cancers, also opnion for Kangri Cancer to be answered
There are various heat induced cancers in world.Duration of exposure,minmum temperature required for inducing pre-malignant changes, sites of cancers are uner review. Mechanism of action is important in these cases Anyone having more knowledge of mechanism of action for Kangri Cancer or other heat induced cancers
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4 Answers 3 Votes
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25 Answers 54 Votes
For respiratory viruses, should folks wear masks in public a) always, b) if they are or may be infected, or c) if they are afraid of getting infected? Are masks a) protection, or b) social signals?
Since 2020, the public has thought of masks as having a protective purpose, and many rebel at the inconvenience, rationalizing that “they do a poor job of protecting.” Is the current epidemic a good opportunity for government and medicine to teach the folks about the more important virtues of using masks to convey information?
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Answer Accepted 2 Answers 0 Votes
What can be expected from the development of preventive vaccines for non virally-induced cancers?
The introduction of prophylactic vaccines for virally-induced cancers (primarily HBV and HPV) has achieved a tremendous impact on disease related deaths. This has, in time, raised interest in developing vaccines to intercept pre-cancerous cells based on their expression of aberrant self-antigens (e.g. hypoglycosilated MUC1 in colon, lung and breast carcinomas). As of 2024, a number of phase I clinical studies have been ongoing in the USA, for both primary prevention and early cancer...
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Answer Accepted 1 Answer 1 Vote
What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?
Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?
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Answer Accepted 1 Answer 0 Votes
What are the current hot topics in the study of critical points during the process of cell mutation and development into tumors? How to conduct in-depth research on the future use of AI?
Tumorigenesis is not a linear accumulation of mutations but rather a dynamic process punctuated by critical transition points—windows during which normal cells cross irreversible thresholds toward dysplasia, carcinoma in situ, and ultimately invasive malignancy. Understanding the molecular and ecological drivers of these “tipping points” is fundamental to early interception and prevention. I would like to ask the cancer biology and computational oncology community: Which specific transition...
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4 Answers 2 Votes
Why are ambitious, planet-critical research proposals, still hitting funding roadblocks, and what will it take to break down these barriers before it’s too late?
Why are we underfunding high-impact climate solutions despite escalating risks—and what funding models would actually move the needle?
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