Pings
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4 Answers 2 Votes
Why are ambitious, planet-critical research proposals, still hitting funding roadblocks, and what will it take to break down these barriers before it’s too late?
Why are we underfunding high-impact climate solutions despite escalating risks—and what funding models would actually move the needle?
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3 Answers 0 Votes
What deep learning strategies best balance accuracy and interpretability in medical image segmentation for disease progression analysis?
Medical imaging (CT/MRI) segmentation is vital for tracking disease, but black-box models reduce clinical trust. Methods like explainable AI (XAI), uncertainty quantification, and hybrid modeling may bridge this gap. What approaches are most promising?
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2 Answers 0 Votes
what are the possible side effects of the use of 5 alpha reductase inhibitors in young men?
what is the incidence of side effects? what are the common side effects and symptoms? what are the genetics and molecular bases for such side effects and symptoms?
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Answer Accepted 2 Answers 0 Votes
How can AI-enhanced modeling reshape climate-resilient water management in data-scarce regions over the next decade?
Water security is becoming one of the most critical challenges of our time, particularly in regions where hydrological data is scarce or unreliable. At the same time, artificial intelligence and machine learning are revolutionizing how we model environmental systems. The question is: Can these technologies bridge the data gap, improve decision-making, and help design sustainable, climate-resilient water management systems? We're looking for scientific insights, innovative use cases, and...
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Answer Accepted 2 Answers 0 Votes
Does Yoghurt, Cheese and Milk consumption reduce gut gram negative bacteria and toxic plasma bacterial lipopolysaccharides?
RELEVANT REFERENCES: 1. Sharma, A and IJ Martins. The role of Microbiota in the pathogenesis of Alzheimer’s disease. Acta Scientific Nutritional Health. 7.7 (2023): 108-118. 2. Bacterial Lipopolysaccharides and Neuron Toxicity in Neurodegenerative Diseases. Neurology Research and Surgery. 2018; 1(1): 1-3. 3. Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. Int J Mol Sci. 201516(12): 29554–29573.
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2 Answers 0 Votes
In austere/conflict settings, when does a complex surgery become ethically unjustifiable due to a lack of postoperative resources for managing complications?
As surgeons, we are trained to operate to solve a clinical problem. However, in severely resource-limited or conflict environments, this principle is constantly tested. Consider a scenario: A surgeon has the technical skill to perform a complex procedure (e.g., a pancreaticoduodenectomy for a tumor, or a complex limb salvage after trauma). However, the hospital lacks a reliable ICU, has inconsistent access to blood products, cannot provide parenteral nutrition, and has limited options for...
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Answer Accepted 1 Answer 0 Votes
Do various CLINICIANS need to monitor Sirtuin 1 gene expression and plasma Sirtuin 1 levels with relevance to various drug therapies in patients?
Specific genes that are involved in anti-aging and epigenetics are sensitive to nutritional regulation, oxidative stress and the development of insulin resistance that can result from changes in cellular chromatin, DNA methylation and histone modifications with relevance to the global chronic disease epidemic. The defective gene in the global chronic disease epidemic has now been linked to the anti-aging gene Sirtuin 1. Nutritional regulation of Sirtuin 1 is critical to nuclear...
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Answer Accepted 1 Answer 0 Votes
Does the anti-aging gene Sirtuin 1 need to be measured in early disease screening in COVID-19 and AIDS patients?
The defective gene in the global chronic disease epidemic has now been linked to the anti-aging gene Sirtuin 1. Sirtuin 1 is now an important gene for consideration in Frontiers and Genetics. Nutritional regulation of Sirtuin 1 is critical to nuclear receptors/transcription factors that are involved with glucose homeostasis, immune system, body temperature regulation, stem cell therapy and mitochondrial biogenesis. Plasma Sirtuin 1 levels may be of critical interest to COVID-19, AIDS and the...
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Answer Accepted 3 Answers 3 Votes
Could the significantly increase in childhood diseases be associated with drug abuse and government (CDC) mandates for over-vaccination of public with pathogen-specific vaccines?
Overview of data on American health status (young and old) and the tremendous cost of healthcare (sick care, drug-dependency and hospitalization) provides compelling evidence that in the twentieth century nearly all classic disease categories (congenital, inherited, neonatal, or induced) that occurred at the rates of 2 to 5 % in the last century, shifted to increase induced diseases (at rates as high as 50 % or more), according to official reports by governmental agencies and private...
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2 Answers 0 Votes
For a change in the peer-reveiwing as an urgent need?
With an increasing number of Journal and other publication, the review by peer started to be difficult and very often nonqualified reviewers are solicited. Very often now the Journal send us a list that ressemble the directory a. This is a problem since many of the persons listed here do not have even a record over 10 and there are supposed to review works they don't know, and they are not qualified. I would like to start a huge discussion that can be sent to the main Journal to change the...
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