Pings
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5 Answers 0 Votes
What deep learning strategies best balance accuracy and interpretability in medical image segmentation for disease progression analysis?
Medical imaging (CT/MRI) segmentation is vital for tracking disease, but black-box models reduce clinical trust. Methods like explainable AI (XAI), uncertainty quantification, and hybrid modeling may bridge this gap. What approaches are most promising?
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2 Answers 0 Votes
Why is the ammonia/ammonium concentration highly increased during storage of human urine?
Hydrolysis of urine Why is the ammonia/ammonium concentration highly increased during storage of human urine?
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Answer Accepted 1 Answer 0 Votes
What are the current hot topics in the study of critical points during the process of cell mutation and development into tumors? How to conduct in-depth research on the future use of AI?
Tumorigenesis is not a linear accumulation of mutations but rather a dynamic process punctuated by critical transition points—windows during which normal cells cross irreversible thresholds toward dysplasia, carcinoma in situ, and ultimately invasive malignancy. Understanding the molecular and ecological drivers of these “tipping points” is fundamental to early interception and prevention. I would like to ask the cancer biology and computational oncology community: Which specific transition...
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Answer Accepted 7 Answers 5 Votes
No threshold approach in the risk assessment of genotoxic carcinogen. Is it still well supported by current knowledge of carcinogenesis?
No threshold approach is routinely applied in the risk assessment of genotoxic carcinogens. How this approach is supported by data? Isn´ t it somewhat obsolete?
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5 Answers 2 Votes
Role of humanized immune system mice in to study the infectious and systemic inflammatory disease.
Whether the humanized immune system (HIS) mice help developing therapeutic interventions against infectious and inflammatory diseases? Whether HIS mice may revolutionize the translational biomedical research
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6 Answers 4 Votes
How might AI-assisted peer review tools reshape scientific publishing, and what safeguards should be implemented to maintain review quality while addressing the increasing volume of submissions?
The peer-reviewing process is being faced with ever-growing challenges as submission rates are still rising exponentially in all areas. Journal editors are faced with the challenge of getting capable reviewers who are ready to volunteer their time, with a result being delays in reviewing, reviewer exhaustion, and worse, compromised quality. Meanwhile, AI technologies are accelerating their ability to review scientific manuscripts for methodology, statistical fitting, plagiarism screenings,...
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5 Answers 1 Vote
For a change in the peer-reveiwing as an urgent need?
With an increasing number of Journal and other publication, the review by peer started to be difficult and very often nonqualified reviewers are solicited. Very often now the Journal send us a list that ressemble the directory a. This is a problem since many of the persons listed here do not have even a record over 10 and there are supposed to review works they don't know, and they are not qualified. I would like to start a huge discussion that can be sent to the main Journal to change the...
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Answer Accepted 2 Answers 0 Votes
How can AI-enhanced modeling reshape climate-resilient water management in data-scarce regions over the next decade?
Water security is becoming one of the most critical challenges of our time, particularly in regions where hydrological data is scarce or unreliable. At the same time, artificial intelligence and machine learning are revolutionizing how we model environmental systems. The question is: Can these technologies bridge the data gap, improve decision-making, and help design sustainable, climate-resilient water management systems? We're looking for scientific insights, innovative use cases, and...
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Answer Accepted 1 Answer 0 Votes
Do various CLINICIANS need to monitor Sirtuin 1 gene expression and plasma Sirtuin 1 levels with relevance to various drug therapies in patients?
Specific genes that are involved in anti-aging and epigenetics are sensitive to nutritional regulation, oxidative stress and the development of insulin resistance that can result from changes in cellular chromatin, DNA methylation and histone modifications with relevance to the global chronic disease epidemic. The defective gene in the global chronic disease epidemic has now been linked to the anti-aging gene Sirtuin 1. Nutritional regulation of Sirtuin 1 is critical to nuclear...
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Answer Accepted 1 Answer 0 Votes
Does the anti-aging gene Sirtuin 1 need to be measured in early disease screening in COVID-19 and AIDS patients?
The defective gene in the global chronic disease epidemic has now been linked to the anti-aging gene Sirtuin 1. Sirtuin 1 is now an important gene for consideration in Frontiers and Genetics. Nutritional regulation of Sirtuin 1 is critical to nuclear receptors/transcription factors that are involved with glucose homeostasis, immune system, body temperature regulation, stem cell therapy and mitochondrial biogenesis. Plasma Sirtuin 1 levels may be of critical interest to COVID-19, AIDS and the...
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