Pings
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6 Answers 0 Votes
What deep learning strategies best balance accuracy and interpretability in medical image segmentation for disease progression analysis?
Medical imaging (CT/MRI) segmentation is vital for tracking disease, but black-box models reduce clinical trust. Methods like explainable AI (XAI), uncertainty quantification, and hybrid modeling may bridge this gap. What approaches are most promising?
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Answer Accepted 2 Answers 0 Votes
Artificial intelligence has brought great hope to advancing our understanding of severe inflammation by simulating complex signal networks and molecular mechanisms that determine disease trajectories.
Artificial intelligence has brought great hope to advancing our understanding of severe inflammation by simulating complex signal networks and molecular mechanisms that determine disease trajectories. The core of this work is pathways such as NF - κ B, MAPK, and JAK-STAT, which regulate the expression of pro-inflammatory cytokines and mediators. These pathways are regulated by post-translational modifications, transcription factor dynamics, and crosstalk with damage associated molecular...
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1 Answer 0 Votes
How does friccohesity chemistry act as global physicochemical property with quantum mechanical activity to nanoformulate the smart cosmetics, syrups, supplements, lubricants, antiwrinkle creams ?
Currently, the friccohesity measured using survismeter has emerged as global physicochemical property of smart research methodologies for nanoformulations to bring all the ingredients in a most aligned coordination for generating the extra mileage of each ingredient for applications.
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5 Answers 0 Votes
What threshold of urinary cadmium (Cd-U) is currently considered indicative of early renal tubular dysfunction in exposed adult populations?
I am conducting a study on chronic environmental cadmium exposure and its nephrotoxic effects, particularly focusing on early biomarkers of renal tubular damage. Several sources suggest 2 µg/g creatinine as a reference point, but variability exists depending on population, sex, and co-exposure. Could experts clarify which threshold (e.g. 1 µg/g, 2 µg/g, or 5 µg/g creatinine) is most reliable or currently used in risk assessments and clinical practice?
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10 Answers 1 Vote
Can we consider that epidrugs can constitute a good therapeutic strategy against cancer diseases?
Recently, it has been demonstrated that epigenetic perturbations are mainly involved in cancer development. Can we consider that epidrugs can constitute a good therapeutic strategy against cancer diseases ?
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25 Answers 54 Votes
For respiratory viruses, should folks wear masks in public a) always, b) if they are or may be infected, or c) if they are afraid of getting infected? Are masks a) protection, or b) social signals?
Since 2020, the public has thought of masks as having a protective purpose, and many rebel at the inconvenience, rationalizing that “they do a poor job of protecting.” Is the current epidemic a good opportunity for government and medicine to teach the folks about the more important virtues of using masks to convey information?
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9 Answers 0 Votes
What is the most important part of a scientific article? Let's approach this seriously!
I read a question asking what is the most important part of a scientific article. As far as I can see, we have all gone crazy. The most significant part of a scientific article is… simply ALL OF IT. By the way, nobody has commented on the REFERENCES. Or is a copy-paste enough?
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Answer Accepted 2 Answers 0 Votes
What can be expected from the development of preventive vaccines for non virally-induced cancers?
The introduction of prophylactic vaccines for virally-induced cancers (primarily HBV and HPV) has achieved a tremendous impact on disease related deaths. This has, in time, raised interest in developing vaccines to intercept pre-cancerous cells based on their expression of aberrant self-antigens (e.g. hypoglycosilated MUC1 in colon, lung and breast carcinomas). As of 2024, a number of phase I clinical studies have been ongoing in the USA, for both primary prevention and early cancer...
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Answer Accepted 1 Answer 1 Vote
What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?
Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?
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Answer Accepted 2 Answers 2 Votes
What constitutes evidence when the links between exposure and outcome are indirect, delayed, or influenced by multiple interacting factors? And how can we strengthen our ability to interpret patterns
In modern research and public health, phenomena occur in complex systems where biological, environmental, and social factors interact over time. Causality is rarely linear or clear. Understanding these requires evaluating study design, uncertainty, and context, and critically analyzing how evidence is generated, interpreted, and used in decision-making.
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