Oxidative Stress as a Precursor and Mechanism for Carcinogenicity
IARC and others (Smith et al) have identified 10 key characteristics which may be used/considered in the evaluation of carcinogenicity, one of which is oxidative stress. How strong or compelling, if at all, would the data need to be for considering OS as a putative and defensible MOA for carcinogenicity, or would there need to be other tangential/correlative data (e.g., tumors) available. In other words, is OS sufficient by itself as an indicator and compelling basis for a carcinogenic concern?
Post an Answer
You must me logged in to answer a question.