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Oxidative Stress as a Precursor and Mechanism for Carcinogenicity

IARC and others (Smith et al) have identified 10 key characteristics which may be used/considered in the evaluation of carcinogenicity, one of which is oxidative stress.  How strong or compelling, if at all, would the data need to be for considering OS as a putative  and defensible MOA for carcinogenicity, or would there need to be other tangential/correlative data (e.g., tumors) available.  In other words, is OS sufficient by itself as an indicator and compelling basis for a carcinogenic concern? 
1
K. Kannan
No, OS is a global marker of stress and is not specific to exposure to chemicals or chemical classes.  Dietary factors can affect oxidative stress levels as well.  Many disease conditions can affect oxidative stress.  Therefore oxidative stress markers alone cannot predict carcinogenicity.
1
Serkan YILMAZ
Carcinogenesis is multistep process and OS is not sufficient by itself as an indicator and compelling basis for a carcinogenic concern

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