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. Is there a test that utilises anti-PSA monoclonal antibodies to localise PSA-avid tumour in the body?

The issue of a persistently rising Prostatic Surface Antigen (PSA) level in blood post prostatectomy for cancer of the prostate remains problematic in clinical practice especially in patients without evidence of local recurrence or metastatic disease on MRI/PET Scan.  
Oncology
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Anshuman Vikram
 No, there isn’t a routine clinical test that uses anti-PSA monoclonal antibodies to locate PSA-producing tumors in the body. While PSA is a helpful blood marker, it’s not used directly for imaging. Instead, doctors rely on a more advanced scan called PSMA PET. This test targets a different protein—PSMA—which is found on most prostate cancer cells. It’s currently the most effective way to find hidden cancer when PSA is rising after prostate surgery, but standard MRI or PET scans don’t show anything. 

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07/12/2025
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