Results
(109 Answers)

Answer Explanations

  • Agree
    user-153519
    Both terms should be removed because it would avoid any discussion on the strict definition of those terms instead of the possible hazard of some chemicals. 
  • Disagree
    user-125195
    Given the uncertainty of knowledge and how laws are written regulators, informed by assessments of risk assessors, need to consider "best available science" and the "weight of evidence" in totality. That said, I note that codified definitions can always be improved and should be reevaluated periodically and refined if/when necessary
  • Disagree
    user-841110
    An emphasis on scientific rigor should be maintained.
  • Disagree
    Sonne72
    Always needed. But it should always be done this way but always good to emphasize though it could be removed.
  • Disagree
    SciPinion Admin
    some definition is needed because that is what scientists strive for implicitly; not saying that the current definition is god, but simply that it is needed, should not be removed and replaced with a void open to interpretation. more precision is criteria is needed, not less.
  • Agree
    user-523578
    Scientific evidence evolves. 
  • Agree
    user-911600
    Speed up production 
  • No opinion
    user-445218
    I am not familiar with the definitions
  • Disagree
    user-568782
    I opt in a possibility for updating according to the evolution of the technology or ethical considerations (industry influence for instance) , instead to remove the codified definitions for "Best available science"...
  • Disagree
    user-153764
    EPA should retain the phrase weight of evidence
  • No opinion
    user-997228
    The removal of codified definitions for terms like "best available science" and "weight of scientific evidence" from regulatory frameworks can have both merits and demerits.


    Arguments in favor of removal:

    1. Flexibility: Eliminating specific definitions can provide more flexibility in interpreting these terms, allowing regulatory agencies to adapt to evolving scientific advancements and methods.
    2. Reduced Rigidity: Removing codified definitions may prevent potential constraints that rigid definitions can impose on scientific advancements and new methodologies.
    3. Avoiding Obsolescence: Definitions can become outdated as scientific knowledge progresses. Eliminating them might prevent regulations from becoming obsolete or inadequate over time.

    Arguments against removal:

    1. Ambiguity: The absence of clear definitions can lead to ambiguity and differing interpretations, potentially resulting in inconsistency in applying these scientific principles across different regulatory decisions.
    2. Lack of Guidance: Clear definitions offer guidance to regulatory agencies, industries, and stakeholders, ensuring a standardized understanding of scientific standards and expectations.
    3. Potential for Misinterpretation: Without explicit definitions, there's a risk of misinterpretation or misuse of scientific principles, leading to less effective decision-making in regulatory processes.
  • Agree
    user-678105
    "weight of scientific evidence" has a psychological component that depends on the evaluator
  • Agree
    user-553839
    The removal will ensure that the ordinary person can also access the nuances of best available science. We should not do science only for scientists but must also take into consideration the common masses. Educating the common people is an excellent idea that will percolate down through the ladder improving the social and societal structure making the community more robust. 


  • Disagree
    user-754769
    Drugs should be defined scientifically and scientific evidence is important.
  • Agree
    user-114825
    Subjective positions
  • Agree
    user-931808
    Leads to ambiguity 
  • Disagree
    user-673903
    These definitions need to be standardized. "Weight of evidence" is very important and highly used. "Best available science" is a moving target currently with the use of computational methods and in silico. Risk assessment agencies may not have the best tools or most qualified persons to perform best available science.  This definition is rather subjective, where weight of evidence is more solid.
  • Disagree
    user-653570
    Definitions for those terms will help to clarify what EPA considers to be the "best available science" or "weight of evidence" rather than leaving it to the reader to define however they wish.  It would be better if EPA was more precise.
  • Disagree
    user-521436
    These are concepts well rooted in risk assessment; and there are ongoing discussions at regulatory levels to clarify the criteria to establish "best available science" and "weight of scientific evidence."  
  • Disagree
    user-574398
    Having some standard /goal to guide both information and conclusions is more helpful than not.
  • Disagree
    user-378118
    Any statement during evaluation of risks, should be backed up by evidence - to go beyond feelings or biases. 
  • Disagree
    user-414626
    Best available means that science that is not at the top of the heap is not considered. In WoSE, all studies are considered and their quality determines the weight. Sometimes the second best and third best studies can provide useful information.
  • Disagree
    user-411596
    The phrases "best available science" and "weight of scientific evidence" are commonly used in scientific and regulatory contexts to describe the quality and reliability of scientific information. These terms are essential for ensuring that decisions, particularly in areas like public health and environmental regulation, are based on sound scientific principles. Removing these codified definitions may have significant consequences for the integrity and transparency of decision-making processes.
  • Agree
    user-691039
    Especialy tox science is heavily hunting for money. Many reports are due to insufficiĆ«ntie methodologie and not enough scrutinizing results. Result a flutter of publications aimed at generating concern ultimatly hunting for funding. Like we have seen in nano tox publicatons 
  • Agree
    user-499245
    These terms are completely subjective and can be used to manipulate the result of the risk assessment.
  • Disagree
    user-697562
    Best available science encompasses not only the weight of scientific evidence but also the quality of available scientific evidences. 
  • Disagree
    user-175854

    Removing these definitions could lead to ambiguity and inconsistency in how scientific evidence is interpreted and applied in risk evaluations, potentially undermining the effectiveness and credibility of the process.
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