Are the assumptions made by the calculators clearly defined in the documentation?

Answer Explanations

• Yes

  Expert 4
  Yes they are all specified.
  
  
• No (please explain)

  Expert 6
  Units of the input parameters need to be clarified.  Also, the absence of assumptions about non-variability in outcome measurement should at least be mentioned.
• Yes

  Expert 7
   An assumption  that sampling and analytical techniques have negligible errors, orders of magnitude smaller than those related to between- and within-person variability in exposure and exposure biomarkers. seems reasonable

   
• Yes

  Expert 1
  Yes, they are clearly laid out in a very readable format with formulas and dot points explaining what each variable represents.
• No (please explain)

  Expert 2
  The documentation clearly states that the calculators assume classical (additive, normally distributed) measurement error. This is a critical assumption that underpins the functionality of the calculators, and it is explicitly mentioned to ensure users understand the basis of the calculations.
  However, the documentation did not outline that the calculators are designed for specific, simplified scenarios, such as focusing on single-exposure variables without considering confounders or complex study designs.