Is there scientific evidence suggesting a close correlation between life stress and the genesis of oxidative stress?

Concrete evidence supports the role of lifestyle and social, occupational, and psychological stress in regulating oxidative stress. For instance, by inducing social defeat in a rat model, inflammation and oxidative stress markers significantly increased in the hippocampus of animals, which was associated with memory impairment (https://www.sciencedirect.com/science/article/abs/pii/S0006899313013073). Similarly, social isolation and loneliness can provoke sympathetic hyperactivation and immune response, releasing numerous inflammatory markers and accentuating oxidative stress. In return, oxidative stress in the rostral ventrolateral medulla is needed for sympathetic nerve activity, forming a futile cycle. This pathway has been implicated in cardiovascular diseases (https://www.sciencedirect.com/science/article/pii/S2213231720302317). There are numerous studies discussing the pathophysiology. 

Moreover, a meta-analysis of 87 studies with 4928 autism spectrum disorder children and 4181 healthy children showed that compared with healthy children, children with autism spectrum disorder have higher blood concentration of oxidative stress markers such as oxidative glutathione (GSSG), malondialdehyde, homocysteine, and S-adenosylhomocysteine (https://www.nature.com/articles/s41398-020-01135-3). However, antioxidants could not markedly improve the outcome of cardiovascular diseases, psychological diseases, and other diseases linked to oxidative stress and social stress.

The imbalance between cellular production of reactive oxygen species and the protective antioxidant systems is known as oxidative stress. The brain is thought to be particularly vulnerable to oxidative stress or redox imbalances due to its high oxygen consumption and environment rich in lipids. Therefore, it is not surprising that oxidative stress is linked to a number of mental diseases, such as depression, anxiety disorders, schizophrenia, and bipolar disorder. The causal association between oxidative stress and psychiatric diseases is not entirely understood, despite the fact that multiple elegant investigations have proven a correlation between oxidative stress and psychiatric disorders.