Can Levodopa and Renin-angiotensin system alter the intercellular tight junction (TJ) proteins in the epithelial cells in colorectal adenocarcinoma cell line (in vitro)?

Colorectal adenocarcinoma cell line (Caco-2) express tight junctions from 17-21 days. Levodopa is the precursor of dopamine, a well-known neurotransmitter, owever it also porduce effect in the gut. The renin-angiotensin system is responsible for maintaining homeostais and regulate blood pressure and volume.