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Can phytoestrogens slow down aging in women?

Phytoestrogens are
a variety of nonsteroidal compounds of plants which are similar to estradiol. They have both anti-estrogenic and estrogen-like effects. It is known that phytoestrogens normalize the condition of the body of women with menopausal syndrome. However, can they compensate for estrogen deficiency and reduce the rate of aging?
Drug Discovery Endocrinology Medicinal chemistry Medicine Nutritional toxicology
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1
Ian James Martins
The anti-aging gene Sirtuin 1 is critical to reverse the aging process. Phytoestrogens can interact with estrogen receptors and influence cellular processes regulated by Sirtuin 1. Phytoestrogens can activate Sirtuin 1 with relevance to the aging process.

RELEVANT REFERENCES:

1.   Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26

2.   Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. 2017;Vol. 3 No. 3:24.

3.   Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes. J Diabetes Metab Disord. 2017; 4: 019.

4.   Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215.

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Alvass
Phytoestrogens' contribution to slowing aging in women is mixed. It could support metabolic health, reduce oxidative stress, and mimick some benefits of estrogen, however, their effects are modest and highly personalised. Always with natural occuring compounds consult your physician. Phytoestrogens may act as weak agonists or antagonists in various tissues. So some studies warn of potential risks in estrogen-receptor-positive cancers.

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Created
06/18/2025
Answer Count
2
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1
Creator
Elena Erofeeva