Does insulin therapy activate the anti-aging gene Sirtuin 1 that is critical for the prevention of insulin iresistance?

 

The anti-aging gene Sirtuin 1 is important to the prevention of accelerated aging and diabetes. Sirtuin 1 activators are critical to the treatment of diabetes, cardiovascular disease and Alzheimer’s disease. Sirtuin 1 inhibitors cause insulin resistance and reduce plasma Sirtuin 1 levels. Insulin therapy is critical to the treatment of diabetes and plasma Sirtuin 1 levels need to be measured with relevance to the treatment and prevention of insulin resistance.

RELEVANT REFERENCES:

1.      Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26.

2.      Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. 2017; Vol. 3 No. 3:24.

3.      Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215.

4.      Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes. J Diabetes Metab Disord. 2017; 4: 019.

5.      Insulin Therapy and Autoimmune Disease with Relevance to Nonalcoholic Fatty Liver Disease. Non Alcoholic Fatty Liver Disease. An Update. IntechOpen. 2018