No threshold approach in the risk assessment of genotoxic carcinogen. Is it still well supported by current knowledge of carcinogenesis?
No threshold approach is routinely applied in the risk assessment of genotoxic carcinogens. How this approach is supported by data? Isn´ t it somewhat obsolete?
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7 Answers
Qin
A large amount of experimental data indicates that carcinogens have actual thresholds, which are related to the saturation of defense mechanisms such as DNA repair and antioxidation. Currently, there is a tendency to be lenient towards those with threshold mechanisms, while being strict towards those without thresholds.
Yasser El-Sayed
The approach isn't obsolete, but it's being refined. Modern risk assessment increasingly incorporates mechanistic understanding while maintaining precaution where uncertainty remains significant.
Leslie Recio
Absolutely not; all genotoxic carcinogens show nonlinear dose response curves based on current studies. The difference between theory and having actual data.
JEK01