No threshold approach in the risk assessment of genotoxic carcinogen. Is it still well supported by current knowledge of carcinogenesis?
No threshold approach is routinely applied in the risk assessment of genotoxic carcinogens. How this approach is supported by data? Isn´ t it somewhat obsolete?
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6 Answers
Yasser El-Sayed
The approach isn't obsolete, but it's being refined. Modern risk assessment increasingly incorporates mechanistic understanding while maintaining precaution where uncertainty remains significant.
JEK01
All carcinogens , genotoxic or nongenotoxic exhibit dose response characteristics including thresholds
Leslie Recio
Absolutely not; all genotoxic carcinogens show nonlinear dose response curves based on current studies. The difference between theory and having actual data.
WD