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What are the current hot topics in oncology, and where is the future of cell, immune, and small molecule therapies headed?

Beyond established CAR-T and checkpoint inhibitors, what emerging trends (e.g., protein degraders, AI-driven drug discovery, off-the-shelf cell therapies) are shaping the next decade of cancer treatment? Which modalities show the most promise for solid tumors?

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Alessandra Rossi
In the field of immunotherapies, preventative vaccines based on aberrant expression of self antigens in pre-cancerous conditions (e.g. colonic or pancreatic polyps) may hold a big potential. There are currently ongoing phase I clinical trials in the US, with the primary endpoint of tolerability and immunogenicity.
For more details please check the following:
Stanton et al. Advances and challenges in cancer  immunoprevention and  immune interception.  J Immunother Cancer 2024
McKeague at al. Preventative Cancer Vaccine-Elicited Human Anti-MUC1 Antibodies Have Multiple Effector Functions. Antibodies (Basel), 2024 
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Created
02/25/2026
Answer Count
1
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Creator
Qin
Tags
Biotechnology Medicine Oncology Pharmacology Stem cells