What technological revolutions are needed for the most likely curative breakthrough in cancer treatment?
What disruptive technological revolutions are most needed to achieve a truly curative breakthrough? For example, universal CAR-T, personalized neoantigen vaccines, in situ gene editing, and new mechanisms to overcome drug resistance and metastasis. Please express your own opinions
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2 Answers
Dr. DA
The most likely curative breakthrough will NOT come from a single technology. It will come from integrating three revolutions:
Ultra-early detection (sensitive liquid biopsy screening every 6 months for all adults over 40)
Immediate personalized intervention (in situ gene editing OR rapid neoantigen vaccine)
Continuous evolutionary monitoring (adaptive therapy + universal CAR-T as salvage)
Without controlling cancer's ability to evolve resistance, any therapy – no matter how powerful – will ultimately fail. The true revolution is shifting our mindset from "killing the enemy" to steering an evolutionary system toward extinction.
Ultra-early detection (sensitive liquid biopsy screening every 6 months for all adults over 40)
Immediate personalized intervention (in situ gene editing OR rapid neoantigen vaccine)
Continuous evolutionary monitoring (adaptive therapy + universal CAR-T as salvage)
Without controlling cancer's ability to evolve resistance, any therapy – no matter how powerful – will ultimately fail. The true revolution is shifting our mindset from "killing the enemy" to steering an evolutionary system toward extinction.
Prof. Ni
1) The essence of cancer is the heterogeneity of various malignant tumors caused by gene mutations. To conquer all heterogeneous solid malignancies, first we have to homogenize them into a common target so that they can be treated or cured by using by the same drug or therapy, which may allow for safe, effective, broad-spectrum, and precise anti-cancer treatment.