Pings
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1 Answer 0 Votes
What are the current hot topics in the study of critical points during the process of cell mutation and development into tumors? How to conduct in-depth research on the future use of AI?
Tumorigenesis is not a linear accumulation of mutations but rather a dynamic process punctuated by critical transition points—windows during which normal cells cross irreversible thresholds toward dysplasia, carcinoma in situ, and ultimately invasive malignancy. Understanding the molecular and ecological drivers of these “tipping points” is fundamental to early interception and prevention. I would like to ask the cancer biology and computational oncology community: Which specific transition...
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Answer Accepted 7 Answers 2 Votes
No threshold approach in the risk assessment of genotoxic carcinogen. Is it still well supported by current knowledge of carcinogenesis?
No threshold approach is routinely applied in the risk assessment of genotoxic carcinogens. How this approach is supported by data? Isn´ t it somewhat obsolete?
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5 Answers 0 Votes
How do microplastic particle sizes influence bioaccumulation and toxicity in freshwater ecosystems?
Microplasticsand plastic particles smaller than 5 mm are increasingly found in rivers, lakes, and reservoirs worldwide. Their small size allows them to be ingested by a wide range of aquatic organisms, potentially moving up the food chain. Research suggests that particle size may influence how these plastics are taken up, accumulate in tissues, and cause physiological effects, but the mechanisms are still not well understood. Understanding these size-dependent effects is essential for...
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2 Answers 0 Votes
After a successful 50 year academic career in physics, electrical engineering, and atmospheric science, and service at the NSF, why should I bother with or care about AI?
If one can be successful in obtaining grant funding, research, teaching, being a department chair and serving for 6 years at the National Science Foundation without AI, why bother with it? I am not being atavistic. I genuinely do not see what the advantages are. I am skeptical but willing to listen to answers from AI enthusiasts.
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2 Answers 1 Vote
How can operando spectroscopy combined with machine learning accelerate the rational design of stable copper-based catalysts for selective CO₂ electroreduction?
Recent work has shown that selective dissolution–redeposition, influenced by oxophilicity and miscibility, reshapes copper bimetallic active sites and drives C₁/C₂ selectivity shifts. Integrating operando characterization with machine-learning-guided design could reveal hidden descriptors and accelerate discovery of highly selective, durable CO₂ reduction catalysts.
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0 Answers 0 Votes
What constitutes evidence when the links between exposure and outcome are indirect, delayed, or influenced by multiple interacting factors? And how can we strengthen our ability to interpret patterns
In modern research and public health, phenomena occur in complex systems where biological, environmental, and social factors interact over time. Causality is rarely linear or clear. Understanding these requires evaluating study design, uncertainty, and context, and critically analyzing how evidence is generated, interpreted, and used in decision-making.
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5 Answers 2 Votes
Role of humanized immune system mice in to study the infectious and systemic inflammatory disease.
Whether the humanized immune system (HIS) mice help developing therapeutic interventions against infectious and inflammatory diseases? Whether HIS mice may revolutionize the translational biomedical research
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3 Answers 0 Votes
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
How can medical microrobots improve our awareness regarding the diagnosis and treatment of diseases?
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5 Answers 0 Votes
How to examine for power of grip in a patient with weakness?
When we do clinical examination for weakness, power is ascertained by MRC grading. However, for grip, MRC grading cannot be used. Is there any method to examine hand grip power other than using dynamometer
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2 Answers 0 Votes
What are essential funding barriers to get an ambitious and pertinent research proposal funded, and how to overcome them ?
We are facing financial issues to perform our African GWAS HBV Research Proposal for around ten years ago. Maybe our topic doesn't meet funders needs or interests. I would like to know my peers' view about the question.
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