Pings
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Answer Accepted 1 Answer 0 Votes
Do various CLINICIANS need to monitor Sirtuin 1 gene expression and plasma Sirtuin 1 levels with relevance to various drug therapies in patients?
Specific genes that are involved in anti-aging and epigenetics are sensitive to nutritional regulation, oxidative stress and the development of insulin resistance that can result from changes in cellular chromatin, DNA methylation and histone modifications with relevance to the global chronic disease epidemic. The defective gene in the global chronic disease epidemic has now been linked to the anti-aging gene Sirtuin 1. Nutritional regulation of Sirtuin 1 is critical to nuclear...
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Answer Accepted 1 Answer 1 Vote
I am the discoverer of Nanopathology. Now I am working in neuropathology. Can someone indicate me where I ?can find /buy samples of brain affected by neurological diseases
I have already analyzed (and published ) analyses of baby brain died for Sudden Infant Death Syndrome. these samples were full of inorganic nanoparticles. I analysed brain samples affected by Fronto Temporal Dementia and they are full of nanoparticles. Now I want to analyse brain samples affected by Alzheimer and Parkinson by mans of a Fiedl Emission Gun Environmental Scanning Electron Microscope coupled with an X ray microsensor of a Energy Dispersive System.Can someone give me indications...
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Answer Accepted 1 Answer 0 Votes
For me-too medical devices, on what basis should manufacturers choose biological tests to conduct?
Manufacturers producing a me-too medical device intended for implantation in the human body, conducting a full biocompatibility study including implantation effect that takes more than one year does not seem logical. With the availability of a reference medical device of the same material & intended use, how can the manufacturer choose the required biological tests?
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Answer Accepted 1 Answer 1 Vote
How the drug dosing space and therapeutic level in term of MTD may best be correlated with pharmacokinetics and body metabolic rate in the subject to gain best possible impact and to minimize the toxicity.
when we recommend the dose of antibiotics like oxytetracycline in animals we usually take into consideration the recommended dose on the label but most of the time the therapeutic effect may not be obtained as suspected. As physician we recommend little bit high dose of the drug in some animals for best results which becomes beyond the regulation authorities to justify. Is it possible to recommend the dosing space or dose of the drug flexible including some criteria of considering BMR of the...
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