To make a conclusion regarding a polymer, are quantities larger than a microgram required for molecular weight analysis?

Answer Explanations

• No

  Expert 3
  Depends on the technique used. Assuming the use of MALDI-MS, then, 1 ug would suffice. 
• No

  Expert 9
  This is outside my expertise, as we have not conducted molecular weight analysis of MNPs.
• No

  Expert 4
  This actually depends on various considerations. Particle size is one the main considerations as there is most likely a negative correlation between particle size and quantity needed. Secondly, the method used is of importance with only limited methods available for molecular weight analysis.
• Yes

  Expert 2
   The molecular weight analysis of a polymer usually requires quantities greater than a microgram. This is necessary due to the fact that most analytical techniques lack the sensitivity to produce accurate or reproducible results with sub-microgram samples. The precise amount varies depending on the sample and on the method, but in general, larger sample masses are needed to obtain a reliable molecular weight determination. 
• No

  Expert 1
  Mass spectrometric methods do not require microgram quantities
• No

  Expert 5
  New developments in spitless Py-GC/MS allow for detection in the low nanogram range.
  https://doi.org/10.1016/j.jaap.2022.105707
  https://doi.org/10.1021/acsestair.3c00035
  
  
• No

  Expert 8
  I'm confused by the question. Molecular weight analysis means GPC or SEC analysis where the molecular mass distribution of the polymer chains within a plastic sample is measured. 
  If the question meant to ask about polymer mass of a particle, that depends on the accuracy and limits of the laboratory's balance.
• Yes

  Expert 6
  Yes, if sample quantity is enough. MW measurement by GPC, can help differentiate between polymer and biological matrices. 
• Yes

  Expert 7
  This depends on the techniques being used.