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Relationship between PM2.5 exposure and mortality

A recent paper reported a meta-regression analysis of pm2.5 exposure and mortality: : https://www.sciencedirect.com/science/article/abs/pii/S0013935118303256?via%3Dihub
Is there a plausible biological mode of action that would support the behavior in the dose-response curve noted in Figure 1?
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SFossati
Adaptation?

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