Pings
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0 Answers 0 Votes
How do you judge as a clinician diagnostic tests in order to give the specific treatment to your patient individually?
the above question is for every specialty.
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6 Answers 0 Votes
What threshold of urinary cadmium (Cd-U) is currently considered indicative of early renal tubular dysfunction in exposed adult populations?
I am conducting a study on chronic environmental cadmium exposure and its nephrotoxic effects, particularly focusing on early biomarkers of renal tubular damage. Several sources suggest 2 µg/g creatinine as a reference point, but variability exists depending on population, sex, and co-exposure. Could experts clarify which threshold (e.g. 1 µg/g, 2 µg/g, or 5 µg/g creatinine) is most reliable or currently used in risk assessments and clinical practice?
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2 Answers 0 Votes
Is the role of ceramides in neurodegenerative diseases?
Ceramides, a class of lipid molecules, have been implicated in the pathogenesis of neurodegenerative diseases. Elevated levels of ceramides have been associated with cellular stress, inflammation, and apoptosis, which are processes involved in neurodegeneration. Researchers are investigating the specific mechanisms through which ceramides contribute to diseases like Alzheimer's and Parkinson's, aiming to understand their role and potential therapeutic interventions targeting ceramide pathways.
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1 Answer 0 Votes
What is the current evidence for GLP1 receptor agonists as disease modifying agents in multiple sclerosis, beyond metabolic and weight effects?
I am conducting a PROSPERO registered systematic review and meta analysis on GLP-1 receptor agonists in multiple sclerosis (CRD420261385854). I am seeking expert perspectives on whether current preclinical and clinical evidence supports a disease modifying mechanism or whether observed benefits are secondary to metabolic and weight improvements.
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19 Answers 1 Vote
Why is there a need for Research and Publication Ethics to be taught at Undergraduate, postgraduate, and PhD levels?
The question concerns the importance of teaching research and publication ethics at different educational levels. Integrating research and publication ethics into education fosters responsible, trustworthy research practices and contributes to the overall advancement of knowledge. You are most welcome to share any specific areas you’d like to explore further and your thoughts about them.
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12 Answers 5 Votes
How to quickly check the purity of primary cultures of neurons
Any quick method to test purity of primary cultures of neurons (after 17 days of culture, right before using them for signaling assays)?
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16 Answers 3 Votes
Any herbal medicines used for hepatitis, possible mechanism of action, and if possible attached pictures of plants with citations
Any herbal medicines used for hepatitis, possible mechanism of action, and if possible attached pictures of plants with citations
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0 Answers 0 Votes
Global disability data is collected using different tools (e.g., Washington Group Short Set vs. country-specific instruments). How much does this impact the trustworthiness of cross-country comparison
• Significantly — comparisons are unreliable • Moderately — some caution is needed • Minimally — most tools capture similar populations • The evidence is not yet sufficient to say • I don't have a clear view on this The world is measuring disability differently.
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Answer Accepted 1 Answer 1 Vote
cancer markers and prediction of treatment and managments of cancer patients?
Which specific multi-omic configurations of cancer stem cell (CSC) markers—such as OCT4, Nanog, and NOX2—are most reliable for predicting clinical resistance to immune checkpoint inhibitors in solid tumors?"
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0 Answers 0 Votes
Can 13-multiplex cytokine profiles predict early-stage CRS and irAEs in immunoncology?
The issue for detecting in daily routine the 13 cytokine multiplex protocol can help clinicians to handle much better cancer patients in order to adust their treatments for managing much better patients to live longer and with dignity?
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