Pings
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3 Answers 0 Votes
What are the most reliable surrogate markers for early diabetic nephropathy progression in primary care settings without access to advanced biomarker panels?
I am an internal medicine physician conducting primary care based research on diabetic nephropathy in Pakistan. In our setting, advanced biomarkers such as KIM-1, NGAL and cystatin C are unavailable. I am seeking expert consensus on which routinely available markers including urine ACR, eGFR trajectory, blood pressure patterns, and HbA1c best predict early CKD progression in T2DM patients in resource limited environment.
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5 Answers 2 Votes
Benchmark Dose Software: BMDS vs. PROAST: Are there important advantages/disadvantages to using one over the other?
Are there important advantages/disadvantages to using one over the other? Are there other software packages (e.g., R-based) that could be used for calculating benchmark doses?
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5 Answers 0 Votes
Relationship between PM2.5 exposure and mortality
A recent paper reported a meta-regression analysis of pm2.5 exposure and mortality: : https://www.sciencedirect.com/science/article/abs/pii/S0013935118303256?via%3Dihub Is there a plausible biological mode of action that would support the behavior in the dose-response curve noted in Figure 1?
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12 Answers 1 Vote
Can we consider that epidrugs can constitute a good therapeutic strategy against cancer diseases?
Recently, it has been demonstrated that epigenetic perturbations are mainly involved in cancer development. Can we consider that epidrugs can constitute a good therapeutic strategy against cancer diseases ?
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6 Answers 0 Votes
In austere/conflict settings, when does a complex surgery become ethically unjustifiable due to a lack of postoperative resources for managing complications?
As surgeons, we are trained to operate to solve a clinical problem. However, in severely resource-limited or conflict environments, this principle is constantly tested. Consider a scenario: A surgeon has the technical skill to perform a complex procedure (e.g., a pancreaticoduodenectomy for a tumor, or a complex limb salvage after trauma). However, the hospital lacks a reliable ICU, has inconsistent access to blood products, cannot provide parenteral nutrition, and has limited options for...
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2 Answers 2 Votes
Can anyone direct me to a good photomicrograph of macrophages in palisades?
I am putting together a PowerPoint on acute and chronic inflammation, and I want to show what it looks like when macrophages form palisades.
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5 Answers 0 Votes
What are recent machanism of actions, minmum duration of years of heat exposure and minimum temperature required for various heat induced skin cancers, also opnion for Kangri Cancer to be answered
There are various heat induced cancers in world.Duration of exposure,minmum temperature required for inducing pre-malignant changes, sites of cancers are uner review. Mechanism of action is important in these cases Anyone having more knowledge of mechanism of action for Kangri Cancer or other heat induced cancers
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7 Answers 1 Vote
Do violations of basic ethical principles in research invalidate the results of a study?
I'm working on an ethics workshop for MSc-level anthropology students on the topic of 'Ethics in the Research of Contemporary Populations'. The question posted here will appear at the end of the class, and I would love to show the students as many answers as possible from scientists. Additionally, if the responses demonstrate significant interest, I will consider public dissemination on social media, so please reply anonymously.
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Answer Accepted 4 Answers 2 Votes
How can universities cultivate a stronger research culture among students? What distinguishes a good researcher from a great researcher?
In your opinion, what are the most effective ways universities and Research institutes can strengthen research culture among students? And what qualities distinguish a good researcher from a truly great researcher? I look forward to hearing perspectives from the academic and research community.
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Answer Accepted 1 Answer 0 Votes
AI has been applied for many years, why can't biotechnology experiments be independently completed on a large scale by AI?
AI has not yet been widely applied in biological experiments involving complex experimental operations, and experimental design, anomaly handling, and ethical supervision still require human judgment. We hope to explore future application scenarios.
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