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18 Answers 22 Votes
Could salary be used as a surrogate for smoking when sample data are lacking?
In epidemiology cohort studies, information on smoking status is often times lacking for the study sample, which makes it challenging to characterize the effects of other risk factors on endpoints that are causally related to smoking (e.g., lung cancer mortality). Given the strong inverse reported for smoking and income, could salary be used as a surrogate for smoking when direct data are lacking? or would potential relationships between salary other risk factors (e.g., health care access)...
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2 Answers 1 Vote
How might AI-assisted peer review tools reshape scientific publishing, and what safeguards should be implemented to maintain review quality while addressing the increasing volume of submissions?
The peer-reviewing process is being faced with ever-growing challenges as submission rates are still rising exponentially in all areas. Journal editors are faced with the challenge of getting capable reviewers who are ready to volunteer their time, with a result being delays in reviewing, reviewer exhaustion, and worse, compromised quality. Meanwhile, AI technologies are accelerating their ability to review scientific manuscripts for methodology, statistical fitting, plagiarism screenings,...
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32 Answers 23 Votes
To what extent can AI be used in scientific writing?
Routine aspects of inspection and considerations include, but not limited to: Obtaining the research question and hypothesis, choosing statistical analytic approaches and methods, data Interpretation, English editing, content Generation, drawing conclusions, etc. These are just several aspects, however, the potential hazards include the risk of bias, uniform tone in writing, lack of creativity, etc. Although with supervised use all these aspects can be partially controlled, to what extend do...
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8 Answers 7 Votes
Do chronic studies in two species provide significant value in drug development?
Chronic studies in rodent (6 months) and non rodent (9 months) are required for approval of a new drug. Results of these studies are not required until the NDA is submitted, i.e. all the clinical trials are complete. The results of these studies are rarely included in the drug label. Since we generally have subchronic data in two species and long-term exposures in carcinogenicity studies, are the required chronic studies adding to patient safety?
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2 Answers 1 Vote
How many samples do you need to analyze for effective blood plasma products quality control?
A blood bank is set up with a laboratory for the preparation of blood components. Product quality control (e.g. plasma sterility) should be performed. How many samples do you need to analyze for effective control? How do you calculate this number? Does it vary depending on the total number of components produced?
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Answer Accepted 25 Answers 20 Votes
AI for academic writing: friend or foe?
Given the increasing availability of AI writing tools, how can academic institutions ensure the responsible use of these technologies while maintaining the integrity of research and scholarship?
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Answer Accepted 1 Answer 0 Votes
For me-too medical devices, on what basis should manufacturers choose biological tests to conduct?
Manufacturers producing a me-too medical device intended for implantation in the human body, conducting a full biocompatibility study including implantation effect that takes more than one year does not seem logical. With the availability of a reference medical device of the same material & intended use, how can the manufacturer choose the required biological tests?
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Answer Accepted 1 Answer 1 Vote
How the drug dosing space and therapeutic level in term of MTD may best be correlated with pharmacokinetics and body metabolic rate in the subject to gain best possible impact and to minimize the toxicity.
when we recommend the dose of antibiotics like oxytetracycline in animals we usually take into consideration the recommended dose on the label but most of the time the therapeutic effect may not be obtained as suspected. As physician we recommend little bit high dose of the drug in some animals for best results which becomes beyond the regulation authorities to justify. Is it possible to recommend the dosing space or dose of the drug flexible including some criteria of considering BMR of the...
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