In your opinion, what are the weaknesses of Pathway Constructs (AOP/MOA)? (Select all that apply)

Answer Explanations

• Other (please explain)

  user-61732

  Relatively new set aspects to put into practice, so time will learn. Very enthusiastic of the initiative.

• Labour intensive to develop Limited coverage (i.e., too few AOPs) Require too much data Limited quantitation to date

  user-75230

  Pretty much what we need to characterize if we wish to transition to more efficient and effective assessment, with adequate consideration of causality

• Labour intensive to develop Limited coverage (i.e., too few AOPs) Limited quantitation to date

  user-390626

  The development of MOA and/or AOP can require a lot of scientific experimentation/data generation.

• Difficult to use Labour intensive to develop Limited coverage (i.e., too few AOPs) Limited quantitation to date

  user-957551

  I'm reminded that sometimes pesticides are registered without knowing the actual AOP for its intended biological effect (i.e., kill insect and weed pests). Sometimes it takes many years to discover the actual AOP leading to the desired effect of the technology. Thus, "labour intensive to develop" is an apt consideration.