What is your confidence in this KMD?

Answer Explanations

• 4 - high confidence

  Expert 13

  No more comments.

• 4 - high confidence

  Expert 10

  Based on avalaible data I am fairly confident.

• 4 - high confidence

  Expert 5

  I don't think any other explanation for the non-linearity is as likely.

• 4 - high confidence

  Expert 12

  As I said in my previous responses, the upper limit of the KMD has been fixed at 30 ppm but based on the figures 5 and 6 it might be 15 or 20 ppm. Accordingly, the authors of the whither paper mentioned that the KMD should be 30 ppm or below. However, the 30 ppm needs more discussion and support, which is not clear from the white paper. There are no discussion comparing the observations of the Figures 5 and 6 versus the other figures and Table 2. Are the threshold (point of non-linearity) in these figures are identical, if not why? Overall, there is no robust discussion on why a KMD relatively equal to 30 ppm or lower than 30 ppm can only be considered compared to 15 ppm, for example. However, the reviewer agrees that this may not have a significant impact on the toxicological risk assessment conceding the already high MOE (Table 31).