Answer Explanations 4

4 - high confidence
Expert 12
As I said in my previous responses, the upper limit of the KMD has been fixed at 30 ppm but based on the figures 5 and 6 it might be 15 or 20 ppm. Accordingly, the authors of the whither paper mentioned that the KMD should be 30 ppm or below. However, the 30 ppm needs more discussion and support, which is not clear from the white paper. There are no discussion comparing the observations of the Figures 5 and 6 versus the other figures and Table 2. Are the threshold (point of non-linearity) in these figures are identical, if not why? Overall, there is no robust discussion on why a KMD relatively equal to 30 ppm or lower than 30 ppm can only be considered compared to 15 ppm, for example. However, the reviewer agrees that this may not have a significant impact on the toxicological risk assessment conceding the already high MOE (Table 31).
4 - high confidence
Expert 5
I don't think any other explanation for the non-linearity is as likely.
4 - high confidence
Expert 10
Based on avalaible data I am fairly confident.
4 - high confidence
Expert 13
No more comments.
2 votes 2 0 votes
Expert 12
04/17/2019 11:16

No more comment considering the already high margin of exposure.

2 votes 2 0 votes
Expert 13
04/19/2019 17:37

No more comment.

0
Expert 10
04/23/2019 10:27

no more comment

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