Answer Explanations 4
Strongly agreeExpert 6
I agree with the conclusion. The NTP (National Toxicology Program) (1985) studies (Toxicology and carcinogenesis studies of Telone II (technical grade 1,3-dichloropropene containing 1% epichlorohydrin as a stabilizer) in F344/N rats and B6C3F1 mice (gavage studies). U.S. Dept. of Health and Human Services, Technical Report Series No. 269. ) used Telone II as the test material and it contained epichlorhydrin, a known mutagen and carcinogen to rodents, and humans (see https://doi.org/10.1016/0165-1110(81)90016-6).
Strongly agreeExpert 5
Only positive responses are at high doses, probably exceeding saturation of GSH.
The case could be made even stronger if the potency of epichlorohydrin can explain tumor incidences in the NTP studies. There were other chemcials such as trichloroethene that were stabilized with epichlorohydrin and were tested by NTP in the 1970 and 80s. The tumor profile and inciences there may be used for further support. What are the other components of the products in 1,3-dichloropropene tested by NTP ? I have more confidence in the newer guideline-compliant studies to inform on the carcinogenicity of 1,3-D since they used a better defined product without a mutagenic stabilizer. In addition, the NTP studies have design and conduct issues that hamper interpretation of the findings
Strongly agreeExpert 9
I agree. I see no reason to consider questionable data when other more definitive data are available.