Answer Explanations 4
I don't think it is necessary to conduct any other study to increase my level of confidence.
Based on the extensive database for this compound, I would not recommend that additional studies be conducted.
If human exposure levels are well below extrapolated threshold doses, the there is no need. However, the additional tests described above would increase my confidence.
I do not think that an additional carcinogenicity study will clarify. Assessment of tumorigenic potential and relevance of the findings needs to integrate mode of action and toxicokinetics as done in the white paper. This should be sufficient for conclusions on potential carcinogenicity